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Anti-phospho-PKCg (Thr655)

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货号：07-879

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 07-879
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-phospho-PKCγ (Thr655) Antibody
Alternate Names
  • PRKCG
  • PKC-gamma
  • PKCC
  • PKCG
  • SCA14
  • Protein Kinase C gamma
References
Product Information
Format Affinity Purified
Applications
Application Anti-phospho-PKCγ (Thr655) Antibody detects level of phospho-PKCγ (Thr655) & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-PKCγ (Thr655).
Host Rabbit
Specificity Recognizes phosphor-PKCγ (Thr655). PKCα and PKCβII may cross react in high expressing cells.
Isotype IgG
Species Reactivity
  • Human
Species Reactivity Note Predicted to cross-react with mouse and rat based on complete sequence homology, but have not been tested.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
Gene Symbol
  • PRKCG
  • SCA14
  • MGC57564
  • PKC-gamma
  • PKCG
  • PKCC
Modifications
  • Phosphorylation
Purification Method ImmunoAffinity Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P05129 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
SIZE: 697 amino acids; 78448 Da
SUBUNIT: Interacts with CDCP1.
DISEASE: SwissProt: P05129 # Defects in PRKCG are the cause of spinocerebellar ataxia 14 (SCA14) [MIM:605361]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of autosomal dominant cerebellar ataxias (ADCA). Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements. Spinocerebellar ataxia is caused by degeneration of the cerebellum with variable involvement of the brainstem and spinal cord.
SIMILARITY: SwissProt: P05129 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.
Molecular Weight 78.5 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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