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Anti-ASPM (rabbit polyclonal)

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货号：09-066

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R, Chp, Pm IHC, ELISA Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 09-066
Description Anti-ASPM Antibody
Alternate Names
  • Abnormal spindle protein homolog
  • Asp homolog
  • asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
  • asp (abnormal spindle)-like, microcephaly associated
  • asp (abnormal spindle)-like, microcephaly associated (Drosophila)
  • microcephaly, primary autosomal recessive 5
Background Information The ASPM gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts (Bond et al., 2002 [PubMed 12355089]). The mouse gene ASPM is expressed specifically in the primary sites of prenatal cerebral cortical neurogenesis.
References
Product Information
Format Affinity Purified
Control
  • Human ductal carcinoma tissue
Presentation Purified rabbit serum in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Applications
Application Anti-ASPM Antibody detects level of ASPM & has been published & validated for use in IH, ELISA.
Key Applications
  • Immunohistochemistry
  • ELISA
Application Notes ELISA: Tested in direct ELISA against the ASPM immunogen.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human ASPM.
Epitope N/A
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes ASPM.
Species Reactivity
  • Human
  • Rat
  • Chimpanzee
  • Primate
Species Reactivity Note Reacts with human. Predicted to react with chimpanzee and primate based on sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The ASPM gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts (Bond et al., 2002 [PubMed 12355089]). The mouse gene ASPM is expressed specifically in the primary sites of prenatal cerebral cortical neurogenesis.
Gene Symbol
  • ASPM
  • ASP
  • Calmbp1
  • MCPH5
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Probable role in mitotic spindle regulation and coordination of mitotic processes By similarity. May have a preferential role in regulating neurogenesis.

SUBCELLULAR LOCATION: Cytoplasm by similarity. Nucleus By similarity. Note: The nuclear-cytoplasmic distribution could be regulated by the availability of calmodulin by similarity.

INVOLVEMENT IN DISEASE: Defects in ASPM are the cause of microcephaly primary type 5 (MCPH5) [MIM:608716]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.

SEQUENCE SIMILARITIES: Contains 2 CH (calponin-homology) domains.

Contains 39 IQ domains.
Molecular Weight 218, 95, 75 kDa Observed UniProtKB/Swiss-Prot entry Q8IZT6 describes 2 isoforms produced by alternative splicing: Isoform 1 at 409.800kDa and Isoform 2 at 217.794kDa. Multiple other isoforms in ref: Human Molecular Genetics, 2005, Vol. 14, No. 15 2155–2165.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Immunohistochemistry Analysis: 1:300 dilution of this antibody detected ASPM in human ductal carcinoma tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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