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Anti-phospho-EGFR (Tyr1069)

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货号：07-715

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H IP, WB Rb Serum Polyclonal Antibody
Description
Catalogue Number 07-715
Replaces 04-339
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-phospho-EGFR (Tyr1069) Antibody
References
Product Information
Format Serum
Applications
Application Detect phospho-EGFR (Tyr1069) using this Anti-phospho-EGFR (Tyr1069) Antibody validated for use in IP & WB.
Key Applications
  • Immunoprecipitation
  • Western Blotting
Biological Information
Immunogen KLH-conjugated, synthetic peptide corresponding to amino acids ...QR(pY)SS..., in which pY corresponds to phospho-tyrosine at residue 1069 of human epidermal growth factor receptor (EGFR)
Host Rabbit
Specificity phospho-EGFR (Tyr1069). Tyr1069 corresponds to the position in the human (isoform a) and mouse precursor proteins. This corresponds to Tyr1044 (indicated as Tyr1045 in several publications) in the mature human and mouse protein, and to Tyr1068 in the rat and pig precursor protein.
Species Reactivity
  • Human
Species Reactivity Note Predicted to cross react with bovine, canine, and porcine based on sequence homology
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • EGFR
  • ERBB1
  • ERBB
  • mENA
Modifications
  • Phosphorylation
Purification Method Serum
UniProt Number
UniProt Summary FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.
SIZE: 1210 amino acids; 134277 Da
SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.
PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].
SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.
Molecular Weight 170-180kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by immunoblot on RIPA lysates from EGF-stimulated A431 cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C from date of shipment
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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