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Anti-Kalirin (rabbit polyclonal IgG)

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货号：07-122

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M, R IP, WB, ICC Rb Purified Polyclonal Antibody
Description
Catalogue Number 07-122
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Kalirin Antibody
References
Product Information
Format Purified
Presentation 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide prior to the addition of glycerol to 30%
Applications
Application Anti-Kalirin Antibody is an antibody against Kalirin for use in IP, WB & IC.
Key Applications
  • Immunoprecipitation
  • Western Blotting
  • Immunocytochemistry
Biological Information
Immunogen GST fusion protein corresponding to residues 517-976 of rat Kalirin, cleaved with thrombin to remove the GST moiety; referred to as JH2582
Host Rabbit
Specificity Kalirin; does not cross react with Trio
Isotype IgG
Species Reactivity
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described.
Gene Symbol
  • KALRN
  • TRAD
  • Hs.8004
  • DUET
  • duo
  • Kalirin
  • FLJ16443
  • DUO
  • HAPIP
Purification Method Protein A chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: O60229 # Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
COFACTOR: Magnesium.
SIZE: 2985 amino acids; 340174 Da
SUBUNIT: Interacts with the C-terminal of peptidylglycine alpha- amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) (By similarity).
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the cytoskeleton.
TISSUE SPECIFICITY: Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.
DOMAIN: SwissProt: O60229 The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity (By similarity).
PTM: Autophosphorylated.
DISEASE: SwissProt: O60229 # Genetic variation in KALRN is associated with susceptibility to coronary heart disease type 5 (CHDS5) [MIM:608901]. CHD is the leading cause of death and disability worldwide. CHD is multifactorial disease with a strong genetic component. Classic epidemiologic studies have revealed many risk factors for CHD, including age, sex, hypertension, dyslipidemia, diabetes mellitus, smoking, and physical inactivity.
SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 CRAL-TRIO domain. & Contains 2 DH (DBL-homology) domains. & Contains 1 fibronectin type-III domain. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain. & Contains 2 PH domains. & Contains 1 protein kinase domain. & Contains 1 RPR domain. & Contains 2 SH3 domains. & Contains 5 spectrin repeats.
MISCELLANEOUS: Called DUO because the encoded protein is closely related to but shorter than TRIO.
Molecular Weight 190, 115, 370 and 420kDa isoforms
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on RIPA lysates from rat brain microsomal protein preparation; long exposure times may be required
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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