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STK Antibody, 20X

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货号：35-002

品牌：Millipore 密理博

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Description
Catalogue Number 35-002
Brand Family Upstate
Trade Name
  • Upstate
Description STK Antibody, 20X
References
Product Information
Format Affinity Purified
Applications
Application STK Antibody, 20X detects level of STK & has been published & validated for use in IP.
Key Applications
  • Immunoprecipitation
Biological Information
Immunogen a proprietary formulation containing STK antibody at 20X concentration for use in KinEASE™ fluorescence polarization assays
Host Mouse
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.
Gene Symbol
  • AKT3
  • PRKBG
  • DKFZP434N0250
  • RAC-gamma
  • PKBG
  • RAC-PK-gamma
  • STK-2
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9Y243 # IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
SIZE: 479 amino acids; 55775 Da
SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.
TISSUE SPECIFICITY: In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.
DOMAIN:SwissProt: Q9Y243 Binding of the PH domain to the phosphatidylinositol 3- kinase alpha (PI(3)K) results in its targeting to the plasma membrane.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 PH domain. & Contains 1 protein kinase domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely used as an STK antibody in KinEASE™ fluorescence polarization assays
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions stable 6 months at -20°C from date of shipment
Packaging Information
Material Size 237 µL
Transport Information
Supplemental Information
Specifications

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