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Anti-Plasminogen/Angiostatin, clone GMA-013, Mouse Monoclonal IgM

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货号：05-862

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H ELISA, WB M Purified Monoclonal Antibody
Description
Catalogue Number 05-862
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Plasminogen/Angiostatin Antibody, clone GMA-013
References
Product Information
Format Purified
Applications
Application This Anti-Plasminogen/Angiostatin Antibody, clone GMA-013 is validated for use in ELISA, WB for the detection of Plasminogen/Angiostatin.
Key Applications
  • ELISA
  • Western Blotting
Biological Information
Immunogen Purified human plasminogen
Clone clone GMA-013
Host Mouse
Specificity Plasminogen (kringles 1-3)
Isotype IgM
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Plasminogen (PLG) is a circulating zymogen that is converted to the active enzyme plasmin by cleavage of the peptide bond between arg560 and val561, which is mediated by urokinase (PLAU; MIM 191840) and tissue plasminogen activator (TPA, PLAT; MIM 173370). The main function of plasmin is to dissolve fibrin (see, e.g., FGA, MIM 134820) clots. Plasmin, like trypsin, belongs to the family of serine proteinases (Miyata et al., 1982 [PubMed 6216475]; Forsgren et al., 1987 [PubMed 3030813]).[supplied by OMIM]
Gene Symbol
  • PLG
  • DKFZp779M0222
  • plasminogen
Purification Method DEAE purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P00747 # Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
SIZE: 810 amino acids; 90569 Da
SUBUNIT: Interacts with AMOT and CSPG4 (also true for angiostatin).
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Present in plasma and many other extracellular fluids. It is synthesized in the kidney.
DOMAIN: SwissProt: P00747 Kringle domains mediate interaction with CSPG4.
PTM: N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity). & In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.
DISEASE: "SwissProt: P00747 # Defects in PLG are a cause of thrombophilia [MIM:188050]; a form of recurrent thrombosis. & Defects in PLG may be associated with ligneous conjunctivitis [MIM:217090]. Ligneous conjunctivitis is an unusual and rare form of chronic conjunctivitis, characterized by chronic tearing and redness of the conjunctivae. Initially, pseudomembranes form on the palpebral surfaces which then progress to thick nodular masses that replace the normal mucosa. Because the pseudomembranes have a woodlike consistency, the disease is termed ""ligneous"" conjunctivitis. The disease may be associated with pseudomembranous lesions of other mucous membranes in the mouth, nasopharynx, trachea, and female genital tract."
SIMILARITY: Belongs to the peptidase S1 family. Plasminogen subfamily. & Contains 5 kringle domains. & Contains 1 PAN domain. & Contains 1 peptidase S1 domain.
MISCELLANEOUS: Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.
Molecular Weight Mr 88kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on human plasminogen
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions stable 2 years at -20°C from date of shipment
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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