Rabbit anti-cyclooxygenase-2 Polyclonal antibody

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Rabbit anti-cyclooxygenase-2 Polyclonal antibody

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货号：AB5118

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
B, H, M, Sh	ELISA, WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	AB5118
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-Cyclooxygenase-2 Antibody
Alternate Names	COX-2 PGHS-2 PHS-2

References

Product Information
Format	Affinity Purified
Presentation	Affinity purified immunoglobulin. Liquid in PBS with 0.1% BSA.

Applications
Application	This Anti-Cyclooxygenase-2 Antibody is validated for use in ELISA, WB for the detection of Cyclooxygenase-2.
Key Applications	ELISA Western Blotting
Application Notes	Western blot: 1-10 μg/mL using Chemiluminescence technique; COX-2 runs as a 68-72KDa protein in most cells, sometimes a 90kDa post-translationally modified form is seen as well. CaCo-2 line extracts (induced with serum or growth factors) are good positive controls. ELISA: 1:10,000 - 1:100,000 using 100 ng of immunogen peptide per well. Optimal working dilutions must be determined by end user.

Biological Information
Immunogen	17 amino acid synthetic peptide corresponding to a sequence near the C-terminus of Human/Mouse/Rat COX-2 coupled to KLH.
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	Cyclooxygenase-2. Two isoforms of Prostaglandin H synthase are well characterized, namely COX1 and COX2. Both forms of COX proteins are membrane associated heme proteins containing cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Non steroidal anti-inflammatory drugs) such as aspirin. COX2 is a 72 kDa protein having 60% homology to COX1. It is induced by cytokines and mitogens and likely plays a role in inflammatory diseases such as rheumatoid arthritis.
Species Reactivity	Bovine Human Mouse Sheep
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_000963.1
Entrez Gene Summary	Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS2, which shows 86% - 89% amino acid sequence identity with mouse, rat, sheep, bovine, horse and rabit PTGS2 proteins, respectively. Human PTGS2 is expressed in a limited number of cell types and regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. The expression of this gene is deregulated in epithelial tumors.
Gene Symbol	PTGS2 PHS-2 COX-2 hCox-2 PGHS-2 PGG/HS COX2 EC 1.14.99.1
UniProt Number	P35354
UniProt Summary	FUNCTION: SwissProt: P35354 # May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group per subunit (By similarity). SIZE: 604 amino acids; 68996 Da SUBUNIT: Homodimer (By similarity). SUBCELLULAR LOCATION: Microsome membrane; Peripheral membrane protein. DISEASE:SwissProt: P35354 # Likely to play a role in inflammatory diseases such as rheumatoid arthritis. SIMILARITY: SwissProt: P35354 ## Belongs to the prostaglandin G/H synthase family. & Contains 1 EGF-like domain. MISCELLANEOUS: This enzyme acts both as a dioxygenase and as a peroxidase. & This enzyme is the target of nonsteroidal anti- inflammatory drugs such as aspirin.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.

Storage and Shipping Information

Storage Conditions

Maintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.