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Anti-HtrA1 Serine Peptidase (rabbit polyclonal)

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货号：AB15852

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R WB Rb Purified Polyclonal Antibody
Description
Catalogue Number AB15852
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-HTRA1 Serine peptidase Antibody
Background Information The defining features of the widely conserved HtrA (high temperature requirement) family of serine proteases are the combination of a catalytic protease domain with one or more C-terminal PDZ domains and reversible zymogen activation. Even though HtrAs have previously been implicated in protein quality control and various diseases, including cancer, arthritis, and neuromuscular disorder, the biology of the human family members is not well understood. New studies suggest that HtrA1 is directly involved in the amyloid pathway as it degrades various fragments of amyloid precursor protein while an HtrA1 inhibitor causes accumulation of amyloid beta in astrocyte cell culture supernatants. Furthermore, HtrA1 colocalizes with amyloid deposits in human brain samples.
References
Product Information
Format Purified
Presentation Liquid in PBS with 0.1% sodium azide.
Applications
Application Anti-HTRA1 Serine peptidase Antibody is an antibody against HTRA1 Serine peptidase for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen Synthetic peptide from human HTRA1 Serine peptidase.
Host Rabbit
Specificity HTRA1 Serine peptidase. By Western blot the antibody reacts with a band at ~ 50 kDa on human heart lysate. An additional band at ~240 kDa may also be seen depending on sample and antibody concentration used.
Species Reactivity
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth.
Gene Symbol
  • HTRA1
  • IGFBP5-protease
  • HtrA
  • HTRA
  • PRSS11
  • ARMD7
  • ORF480
  • L56
  • EC 3.4.21.-
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q92743 # Protease that regulate the availability of IGFs by cleaving IGF-binding proteins.
SIZE: 480 amino acids; 51287 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in a variety of tissues, with strongest expression in placenta.
DISEASE: SwissProt: Q92743 # Variations in the promoter region of HTRA1 are the cause of susceptibility to age-related macular degeneration type 7 (ARMD7) [MIM:610149]. ARMD is the leading cause of vision loss and blindness among older individuals in the developed word. It is classified as either dry (nonneovascular) or wet (neovascular). ARMD7 is a wet form, in which new blood vessels form and break beneath the retina. This leakage causes permanent damage to surrounding retinal tissue, distorting and destroying central vision. Wet ARMD is more prevalent among Asians than Caucasians.
SIMILARITY: SwissProt: Q92743 ## Belongs to the peptidase S1B family. & Contains 1 IGFBP N-terminal domain. & Contains 1 Kazal-like domain. & Contains 1 PDZ (DHR) domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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