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Qiagen 凯杰 Biosharp Omega

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Anti-IL-2 Receptor a, clone 7G7/B6

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号:05-170

牌:Millipore 密理博

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Replacement Information

重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H DB, ICC M Purified Monoclonal Antibody
Description
Catalogue Number 05-170
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-IL-2 Rα Antibody, clone 7G7/B6
References
Product Information
Format Purified
Control
  • Lung tissue
Presentation Protein G Purified immunoglobulin in Protein G Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide as a preservative.
Applications
Application This Anti-IL-2 Rα Antibody, clone 7G7/B6 is validated for use in DB, IC for the detection of IL-2 Rα.
Key Applications
  • Dot Blot
  • Immunocytochemistry
Biological Information
Immunogen Whole cells expressing human IL-2 Receptor α
Clone 7G7/B6
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Recognizes interleukin-2 receptor.
Isotype IgG2a
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown.
Gene Symbol
  • IL2RA
  • CD25
  • IL2-RA
  • IL-2-RA
  • OTTHUMP00000044870
  • TCGFR
  • IL2R
  • IDDM10
  • p55
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P01589 # Receptor for interleukin-2.
SIZE: 272 amino acids; 30819 Da
SUBUNIT: Non-covalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DISEASE:SwissProt: P01589 # Genetic variations in IL2RA are associated with susceptibility to insulin-dependent diabetes mellitus type 10 (IDDM10) [MIM:601942].
SIMILARITY: SwissProt: P01589 ## Contains 2 Sushi (CCP/SCR) domains.
Molecular Weight 55 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated on ice cold ethanol/acetic acid [95:5] fixed phytohemagglutinin (PHA)-treated Jurkat T lymphocytes
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Lyophilized: 2 years at -20°C; Rehydrated: 6 months at -20°C
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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