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Anti-Cortactin (p80/85), clone 4F11

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货号：05-180

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Av, B, H, Ht, M, R ICC, IHC, IP, WB M Purified Monoclonal Antibody
Description
Catalogue Number 05-180
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Cortactin (p80/85) Antibody, clone 4F11
Background Information Cortactin is present as a p80 and p85 kDa protein in many cell types.  The protein was first identified as being a major substrate of the tyrosine kinase pp60SRC. The main structural feature of the protein is that at the N-terminus there are five and a half 37-amino acid repeats, these appear to be responsible for the actin-binding.  This repeat region occupies about a third of the protein.  The repeat region is followed by a helical region and then a proline rich region and finally at the C-terminus, an SH3 domain.  The proline rich domain is thought to bind the SH2 domain of v-src the viral version of the normal c-src known to phosphorylate cortactin.  Cortactin bundles microfilaments and this bundling is inhibited by tyrosine phosphorylation.  One pathway that activates the pathway leading to tyrosine phosphorylation of cortactin results from a cell adhesion molecule in brain micro-vessel endothelial cells, another is the growth factor, but presumably the very many mechanisms for pp60src activation would also result in cortactin phosphorylation and subsequent loss of actin binding. 
References
Product Information
Format Purified
Control
  • Positive Control Included: 3T3 Cell Lysate (12-305) Other controls: PC-12 cell lysate, HeLa whole cell lysate or A-431 whole cell lysate
Presentation Purified immunoglobulin in 10mM PBS, pH 7.4 with 0.05% sodium azide.
Applications
Application Anti-Cortactin (p80/85) Antibody, clone 4F11 is an antibody against Cortactin (p80/85), and has been published and validated for use in IC, IH, IP and WB.
Key Applications
  • Immunocytochemistry
  • Immunohistochemistry
  • Immunoprecipitation
  • Western Blotting
Biological Information
Immunogen Mixture of affinity-purified tyrosine phosphoproteins from chick embryo fibroblasts expressing activated pp60src
Clone 4F11
Host Mouse
Specificity Recognizes Cortactin.
Isotype IgG1
Species Reactivity
  • Avian
  • Bovine
  • Human
  • Hamster
  • Mouse
  • Rat
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.
Gene Symbol
  • CTTN
  • EMS1
  • Amplaxin
  • FLJ34459
  • 1110020L01Rik
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q14247 # May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.
SIZE: 550 amino acids; 61636 Da
SUBUNIT: Interacts with SHANK2 and SHANK3 via its SH2 domain. Also interacts with FGD1 (By similarity). Interacts with PLXDC2.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, ruffle (By similarity). Note=Associated with membrane ruffles and lamellipodia (By similarity).
SIMILARITY: SwissProt: Q14247 ## Contains 7 cortactin repeats. & Contains 1 SH3 domain.
Molecular Weight 80 kDa and 85 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated in mouse 3T3/A31 cell lysates or chicken fibroblast src-transformed cell lysate
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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