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Anti-Aquaporin 4 (rabbit polyclonal)

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货号：AB2218

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB2218
Replaces AB3068
Trade Name
  • Chemicon
Description Anti-Aquaporin 4 Antibody
Alternate Names
  • AQP4
  • WCH4
  • MIWC
Background Information The water-specific channel Aquaporin 4 is located in various tissues including the gastro intestinal tract, kidney and brain. It is an osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. The localization of AQ4 to astrocyte endfeet makes it an excellent marker for astrocyte distal processes.
References
Product Information
Format Affinity Purified
Control
  • Tested on adult rat brain lysate
Presentation Purified in PBS with 0.05% NaN3
Applications
Application Anti-Aquaporin 4 Antibody is an antibody against Aquaporin 4 for use in WB.
Key Applications
  • Western Blotting
Application Notes Western Blotting: 0.5-1 μg/mL using Chemiluminescence technique.

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic Linear Peptide
Epitope C-Terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes Aquaporin 4.
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity Note The antibody has not yet been tested for cross-reactivity to other species.


The immunogen shows 94% similarity to mouse, 88% to bovine, 86% to rabbit and 82% to human AQP4 (hAQP4).
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Gene Symbol
  • AQP4
  • MIWC
  • WCH4
  • AQP-4
  • aquaporin-4
  • HMIWC2
  • Aquaporin-4
  • MGC22454
Purification Method ImmunoAffinity Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P55087 # Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
SIZE: 323 amino acids; 34830 Da
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Brain - muscle > heart, kidney, lung, and trachea.
DOMAIN: SwissProt: P55087 Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
Molecular Weight ~34 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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