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Anti-AIF (rabbit polyclonal IgG)

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货号：07-208

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB Rb Purified Polyclonal Antibody
Description
Catalogue Number 07-208
Replaces 04-430
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-AIF (Apoptosis Inducing Factor) Antibody
References
Product Information
Format Purified
Presentation 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Applications
Application Anti-AIF (Apoptosis Inducing Factor) Antibody detects level of AIF (Apoptosis Inducing Factor) & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen peptide corresponding to amino acids 593-606 of human Apoptosis Inducing Factor, AIF (C-KDGEQHEDLNEVAK), containing a N-terminal cysteine
Host Rabbit
Specificity AIF
Isotype IgG
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Three alternative transcripts encoding different isoforms have been identified for this gene.
Gene Symbol
  • AIFM1
  • MGC111425
  • PDCD8
  • AIF
Purification Method Protein A chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: O95831 # Probable oxidoreductase that acts as a caspase- independent mitochondrial effector of apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large scale DNA fragmentation (in vitro).
COFACTOR: FAD.
SIZE: 613 amino acids; 66901 Da
SUBUNIT: Binds to DNA in a sequence-independent manner.
SUBCELLULAR LOCATION: Mitochondrion intermembrane space. Nucleus. Note=Translocated to the nucleus upon induction of apoptosis.
SIMILARITY: SwissProt: O95831 ## Belongs to the FAD-dependent oxidoreductase family.
Molecular Weight 57kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on a mouse liver preparation
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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