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Anti-Surfactant Protein B (rabbit antiserum)

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货号：07-614

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M IHC, WB Rb Serum Polyclonal Antibody
Description
Catalogue Number 07-614
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Surfactant Protein B Antibody
References
Product Information
Format Serum
Presentation rabbit antiserum containing 0.05% sodium azide before the addition of glycerol to 30%
Applications
Application Anti-Surfactant Protein B Antibody is an antibody against Surfactant Protein B for use in IH & WB.
Key Applications
  • Immunohistochemistry
  • Western Blotting
Biological Information
Immunogen Purified human surfactant protein B
Host Rabbit
Specificity Surfactant Protein B
Isotype IgG
Species Reactivity
  • Human
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Summary The SFTPB gene encodes the pulmonary-associated surfactant B protein (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a lipid-rich material that prevents lung collapse by lowering surface tension at the air-liquid interface in the alveoli of lung. SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Surfactant is composed of phospholipids and other surfactant-associated proteins (Clark et al., 1995 [PubMed 7644495]). See also SFTPA1 (MIM 178630), SFTPC (MIM 178620), and SFTPD (MIM 178635).[supplied by OMIM]
Gene Symbol
  • SFTPB
  • SP-B
  • SFTP3
  • Phe
  • PSP-B
  • SFTB3
  • SMDP1
Purification Method Serum
UniProt Number
UniProt Summary FUNCTION: SwissProt: P07988 # Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
SIZE: 381 amino acids; 42117 Da
SUBUNIT: Homodimer; disulfide-linked.
SUBCELLULAR LOCATION: Secreted, extracellular space.
DISEASE: SwissProt: P07988 # Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:265120]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. Inborn errors of pulmonary surfactant metabolism are genetically heterogeneous disorders resulting in severe respiratory insufficiency or failure in full-term neonates or infants. These disorders are associated with various pathologic entities, including pulmonary alveolar proteinosis (PAP), desquamative interstitial pneumonitis (DIP), or cellular non- specific interstitial pneumonitis (NSIP).
SIMILARITY: SwissProt: P07988 ## Contains 1 saposin A-type domain. & Contains 3 saposin B-type domains.
MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
Molecular Weight 8kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on human bronchiolar lavage fluid.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 50 µL
Transport Information
Supplemental Information
Specifications

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