Anti-Histone H2A.X, Human (rabbit polyclonal) - 炼石商城

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Anti-Histone H2A.X, Human (rabbit polyclonal)

市场价：: 0.00

促销价：: ¥0.00

货号：AB10022

品牌：Millipore 密理博

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北京朝阳

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M, R, B	WB, FC	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	AB10022
Brand Family	Upstate
Trade Name	Chemicon
Description	Anti-Histone H2A.X Antibody
Alternate Names	Histone H2A.X Histone H2AX H2a/x Histone H2A.X H2AFX
Background Information	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. H2A.X, also known as H2AFX, is a variant of Histone H2A that is found in a subset of nucleosomes. H2A.X has a unique C-terminal tail that becomes phosphorylated following double-stranded DNA breaks following irradiation or apoptosis. H2AX is involved in DNA repair and the maintenance of genomic stability. It is been implicated both in homologous recombination and nonhomologous end joining DNA repair pathways. H2A.X is thought to have a critical function in the recruitment of DNA repair factors and DNA damage-signaling proteins. H2A.X is ubiquitinated by RING1 and RNF2/RING2 complex providing a specific mark for transcriptional repression. In addition, this protein can be ubiquitinated by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168 as result of double-stranded DNA breaks to recruit repair proteins at a damaged site.

References

Product Information
Format	Affinity Purified
Presentation	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Applications
Application	Use Anti-Histone H2A.X Antibody, Human (Rabbit Polyclonal Antibody) validated in WB to detect Histone H2A.X also known as H2AFX.
Key Applications	Western Blotting Flow Cytometry
Application Notes	Western Blotting Analysis: A 1:10,000 dilution of this antibody detected 500 ng of recombinant Histone H2A.X. Western Blotting Analysis: A 1:10,000 dilution of this antibody detected Histone H2A.X in 10 µg of Rat2 acid extract, BALB 3T3/A31 acid extract, and calf thymus histone extract tissue lysate. Flow Cytometry Analysis: 1.0 µg of this antibody from a representative lot detected Histone H2A.X in 1X10E6 HeLa cells.

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to the C-terminus of human Histone H2A.X.
Epitope	a.a. 121-139
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Species Reactivity	Human Mouse Rat Bovine
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_002096
Gene Symbol	H2AFX H2AX
Purification Method	Peptide affinity chromatography
UniProt Number	P16104
Molecular Weight	~16 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in HeLa acid extract. Western Blotting Analysis: A 1:10,000 dilution of this antibody detected Histone H2A.X in 10 µg of HeLa acid extract.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Packaging Information
Material Size	100 µL

Transport Information

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