Anti-MDM2, clone IF2, Alexa Fluor?488 Conjugate - 炼石商城

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Anti-MDM2, clone IF2, Alexa Fluor?488 Conjugate

市场价：: 0.00

促销价：: ¥0.00

货号：MABE340-AF488

品牌：Millipore 密理博

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	ICC	M	AlexaFluor®488	Monoclonal Antibody

Description
Catalogue Number	MABE340-AF488
Description	Anti-MDM2 Antibody, clone IF2, Alexa Fluor® 488 Conjugate
Alternate Names	E3 ubiquitin-protein ligase Mdm2 Double minute 2 protein Hdm2 Oncoprotein Mdm2 p53-binding protein Mdm2
Background Information	E3 ubiquitin-protein ligase Mdm2 (UniProt Q00987; also known as Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2) is encoded by the MDM2 gene (Gene ID 4193) in human. MDM2 is an E3 ubiquitin ligase that is most widely studied for its role in regulating the p53 tumor suppressor. MDM2 antagonizes p53 transcriptional activity by binding to and blocking p53 N-terminal trans-activation domain. MDM2 can also monoubiquitinate p53, thereby promoting p53 cytoplasmic localization to prevent p53 nuclear funtion. In addition, MDM2, when in complex with p300, also mediates p53 polyubiquitination, resulting in p53 proteosomal degradation. MDM2 overexpression is shown to inhibit DNA double-strand break repair mediated through its interaction with Nbs1 in a p53-independent manner.

References

Product Information
Format	AlexaFluor®488
Presentation	Purified mouse monoclonal IgG2b antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.

Applications
Application	This Anti-MDM2 Antibody, clone IF2, Alexa Fluor® 488 Conjugate is validated for use in Immunocytochemistry for the detection of MDM2.
Key Applications	Immunocytochemistry
Application Notes	Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected MDM2 in A431 cells. The unconjugated antibody (Cat. Nos. MABE340 & OP46) is shown to be suitable also for immunohistochemistry and Western blotting applications.

Biological Information
Immunogen	Recombinant human MDM2.
Epitope	Within amino acids 26-169.
Clone	IF2
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Specificity	Clone IF2 recognizes the ~85/90 kDa (apparent MW) MDM2, as well as isoforms of ~57/60 kDa and ~74/76 kDa by immunoblotting using the unconjugated antibody (Cat. Nos. MABE340 & OP46).
Isotype	IgG2b
Species Reactivity	Human
Species Reactivity Note	Human.
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_002383
Gene Symbol	MDM2
Purification Method	Protein G purified.
UniProt Number	Q00987
Molecular Weight	~85 kDa observed.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Immunocytochemistry in HeLa cells. Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected MDM2 in HeLa cells.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

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