Anti-IL-6R-alpha, clone 1C2 (mouse monoclonal) - 炼石商城

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Anti-IL-6R-alpha, clone 1C2 (mouse monoclonal)

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货号：04-1581

品牌：Millipore 密理博

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北京朝阳

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, NEUT	M	Purified	Monoclonal Antibody

Description
Catalogue Number	04-1581
Description	Anti-IL-6R-alpha Antibody, clone 1C2
Alternate Names	interleukin 6 receptor IL-6R subunit alpha Membrane glycoprotein 80 CD126 antigen interleukin-6 receptor subunit alpha IL-6 receptor subunit alpha interleukin 6 receptor alpha subunit
Background Information	The interleukin-6 receptor (IL-6R) is thought to be made up of two subunits: IL-6R-alpha and gp130. IL-6R-alpha is ligand specific while signal transduction is regulated by gp130. IL-6R is commonly membrane bound but can also be found in a soluble form. It has been found to be inactivated by Porphyromonas gingivalis during infection, most possibly by damaging or inactivating the gp130 subunit of the receptor. IL-6R expression has been linked to aggressiveness of papillary thyroid cancers and medullary thyroid cancers and has also been linked to certain osteoarticular diseases. Recent data has found an association between a certain IL-6R polymorphism and susceptibility to respiratory infections.

References

Product Information
Format	Purified
Control	Human IL-6R recombinant protein
Presentation	Purified mouse monoclonal IgG1κ in PBS with no preservative.

Applications
Application	Anti-IL-6R-alpha Antibody, clone 1C2 detects level of IL-6R-alpha & has been published & validated for use in WB, NEUT.
Key Applications	Western Blotting Neutralizing
Application Notes	Neutralizing Assay Analysis: A previous lot was used by an independent laboratory in NEUT. (Dr. Gerard Zurawski, Baylor College of Dentistry)

Biological Information
Immunogen	Cohesin-tagged recombinant protein corresponding to human IL-6R-alpha.
Clone	AB42.52.1C5.1C2
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Isotype	IgG1κ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_000556
Entrez Gene Summary	Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. The protein encoded by this gene is a subunit of the receptor complex for IL6. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].
Gene Symbol	CD126 gp80 IL-6R 1 IL-6RA IL6RA IL-6R-alpha IL-6R-1
Purification Method	Protein G
UniProt Number	P08887
UniProt Summary	FUNCTION: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. SUBUNIT STRUCTURE: Hexamer of two molecules each of IL6, IL6R and IL6ST. SUBCELLULAR LOCATION: Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein Isoform 2: Secreted TISSUE SPECIFICTY: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum. DOMAIN: The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. PTM: A short soluble form may also be released from the membrane by proteolysis. SEQUENCE SIMILARITIES: Belongs to the type I cytokine receptor family. Type 3 subfamily. Contains 1 fibronectin type-III domain. Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Molecular Weight	~50 kDa observed

Physicochemical Information

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Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blot in human IL-6R recombinant protein. Western Blot Analysis: 1 µg/mL of this antibody detected IL-6R-alpha on 10 µg of human IL-6R recombinant protein.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µg

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