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Anti-PI3 Kinase b, p110b, clone 8C3.2 (mouse monoclonal)

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货号：05-1558

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R, H, M WB, ICC M Purified Monoclonal Antibody
Description
Catalogue Number 05-1558
Replaces 04-400
Description Anti-PI3 Kinase b Antibody, p110b, clone 8C3.2
Alternate Names
  • PI3-kinase p110 subunit beta
  • PtdIns-3-kinase p110
  • phosphatidylinositol 3-kinase, catalytic, beta polypeptide
  • phosphoinositide-3-kinase, catalytic, beta polypeptide
  • PI3K beta
  • PI3 K beta
  • PI3 kinase b
Background Information PI3 Kinase (Phosphatidylinositol 3-Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospho-lipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the β:γ subunits of heterotrimeric G-proteins. PI3 Kinase is inhibitable by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway.
References
Product Information
Format Purified
Control
  • PC-12 cell lysate
Presentation Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Applications
Application This Anti-PI3 Kinase b Antibody, p110b, clone 8C3.2 is validated for use in WB, IC for the detection of PI3 Kinase b.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application Notes Immunocytochemistry Analysis: A 1:500 dilution positively stained NIH3T3 cell lysate.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the N-terminus of human PI3 Kinase b.
Epitope N-terminus
Clone 8C3.2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes PI3 Kinase b at the N-terminus.
Isotype IgMκ
Species Reactivity
  • Rat
  • Human
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993 [PubMed 8246984]).[supplied by OMIM].
Gene Symbol
  • PIK3CB
  • PI3Kbeta
  • PIK3C1
Purification Method Ion Exchange
UniProt Number
UniProt Summary FUNCTION: Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.

CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.

PATHWAY: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.

SUBUNIT STRUCTURE: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit.

TISSUE SPECIFICITY: Expressed ubiquitously.

SEQUENCE SIMILARITIES: Belongs to the PI3/PI4-kinase family.

Contains 1 PI3K/PI4K domain.
Molecular Weight ~110 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in PC-12 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected PI3 Kinase b on 10 µg of PC-12 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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