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Anti-Cdc25C, clone TC-15

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货号：05-507

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M IP, WB, ICC M Purified Monoclonal Antibody
Description
Catalogue Number 05-507
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Cdc25C Antibody, clone TC-15
Background Information The activity of cyclin-dependent kinases is regulated by their phosphorylation status, which is controlled by the antagonistic action of CDC25 phosphatases. Three CDC25 genes are present in human cells: CDC25A, CDC25B and CDC25C. CDC25C is a ~56 kDa dual specific protein phosphatase that controls entry into mitosis by regulating the dephosphorylation of the Cdk1/cyclin B complex. Phosphorylation of Cdc25C creates a binding site for 14-3-3 protein which inhibits Cdc25C. This prevents activation of the Cdk1/cyclin B complex and prevents mitotic entry. Cdc25C is phosphorylated by checkpoint kinases throughout interphase but becomes dephosphorylated during mitosis. Cdc25C is also regulated by p53 via a p53 response element in its promoter, and it is predominantly expressed in the G2 phase of the cell cycle.
References
Product Information
Format Purified
Control
  • HeLa nuclear extract
Presentation 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Applications
Application Detect Cdc25C with Anti-Cdc25C Antibody, clone TC-15 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB, ICC.
Key Applications
  • Immunoprecipitation
  • Western Blotting
  • Immunocytochemistry
Biological Information
Immunogen GST fusion-protein corresponding to residues 1-258 of human cdc25C. Epitope mapped to residues 222-246.
Clone clone TC-15
Host Mouse
Specificity cdc25C
Isotype IgG1κ
Species Reactivity
  • Human
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.
Gene Symbol
  • CDC25C
  • CDC25
Purification Method Protein G Chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: P30307 # Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity.
SIZE: 473 amino acids; 53365 Da
SUBUNIT: Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity.
SUBCELLULAR LOCATION: Nucleus.
DEVELOPMENTAL STAGE: Expressed predominantly in G2 phase.
PTM: Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase.
SIMILARITY: SwissProt: P30307 ## Belongs to the MPI phosphatase family. & Contains 1 rhodanese domain.
Molecular Weight 58kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on HeLa nuclear extract
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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