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Anti-ORC6, clone 3A4

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货号：05-938

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, ChIP R Purified Monoclonal Antibody
Description
Catalogue Number 05-938
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-ORC6 Antibody, clone 3A4
References
Product Information
Format Purified
Applications
Application Anti-ORC6 Antibody, clone 3A4 is a high quality Rat Monoclonal Antibody for the detection of ORC6 & has been validated in ChIP & WB.
Key Applications
  • Western Blotting
  • Chromatin Immunoprecipitation (ChIP)
Biological Information
Immunogen Full-length human origin recognition complex 6 (ORC6). Clone 3A4.
Clone clone 3A4
Host Rat
Specificity ORC6
Isotype IgG2a
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.
Gene Symbol
  • ORC6L
  • ORC6
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9Y5N6 # Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.
SIZE: 252 amino acids; 28107 Da
SUBUNIT: ORC is composed of six subunits. Interacts with DBF4 (By similarity).
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: SwissProt: Q9Y5N6 ## Belongs to the ORC6 family.
Molecular Weight 30kDa. A non specific protein was also detected at Mr 120kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by immunoblot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C from date of shipment
Packaging Information
Material Size 50 µL
Transport Information
Supplemental Information
Specifications

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