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Anti-TM7SF2 (rabbit polyclonal)

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货号：06-1026

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, B, Rhesus Macaque WB, ICC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 06-1026
Description Anti-TM7SF2 Antibody
Alternate Names
  • Delta(14)-sterol reductase
  • Delta-14-SR
  • Another new gene 1 protein
  • C-14 sterol reductase
  • Putative sterol reductase SR-1
  • Sterol C14-reductase
  • Transmembrane 7 superfamily member 2
Background Information Sterol Delta-14 reductase, also known as TM7SF2 and NET47, is important in the conversion of lanosterol to cholesterol, an essential cellular metabolic process, in many mammalian species. This protein is a multipass membrane protein typically found in the endoplasmic reticulum.
References
Product Information
Format Affinity Purified
Control
  • Human brain tissue lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-TM7SF2 Antibody is a Rabbit Polyclonal Antibody for detection of TM7SF2 also known as Delta(14)-sterol reductase, Putative sterol reductase SR-1 & has been validated in WB, ICC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application Notes Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in HeLa cells. (Image courtesy of Dr. Eric C. Schirmer, The Wellcome Trust Centre for Cell Biology, University of Edinburgh)
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human TM7SF2.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Species Reactivity
  • Human
  • Bovine
  • Rhesus Macaque
Species Reactivity Note Demonstrated to react with human. Predicted to react with bovine and rhesus monkey based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • TM7SF2
  • ANG1
  • NET47
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Involved in the conversion of lanosterol to cholesterol.

CATALYTIC ACTIVITY: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol + NADPH.

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein

TISSUE SPECIFICTY: Expressed in adult heart, brain, pancreas, lung, liver, skeletal muscle, kidney, ovary, prostate, and testis, but not detected in placenta, spleen, thymus, small intestine, colon (mucosal lining), or peripheral blood leukocytes.

SEQUENCE SIMILARITIES: Belongs to the ERG4/ERG24 family.

SEQUENCE CAUTION: The sequence AAC21450.1 differs from that shown. Reason: Sequencing errors.

The sequence AAC21457.1 differs from that shown. Reason: Sequencing errors.
Molecular Weight ~50 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in human brain tissue lysate.

Western Blot Analysis: 5 µg/mL of this antibody detected TM7SF2 on 10 µg of human brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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