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Anti-March5 (rabbit polyclonal)

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货号：06-1036

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB, ICC Rb Serum Polyclonal Antibody
Description
Catalogue Number 06-1036
Description Anti-March5 Antibody
Alternate Names
  • membrane-associated ring finger (C3HC4) 5
  • Membrane-associated RING finger protein 5
  • RING finger protein 153
  • E3 ubiquitin-protein ligase MARCH5
  • Mitochondrial ubiquitin ligase
  • Membrane-associated RING-CH protein V
Background Information Membrane-associated RING-CH protein 5 (March5), also known as NKP66, is thought to be a mitochondrial ubiquitin ligase that is localized on the mitochondrial membrane. March5 has a Plant Homeo-Domain (PHD) motif that is essential for E3 ubiquitin ligase action. MARCH 5 is also thought to have four transmembrane domains. March5 has been associated with mitochondrial fission and division. March5 also seems to have a defensive role against mitochondrial dysfunction by interacting with mutant superoxide dismutase 1 (mSOD1) and preventing mSOD1 from causing damage. mSOD1 damage has been linked to the onset and progression of amyotrophic lateral sclerosis.
References
Product Information
Format Serum
Control
  • HL-60 cell lysate
Presentation Rabbit polyclonal serum containing 0.05% sodium azide.
Applications
Application Anti-March5 Antibody is a Rabbit Polyclonal Antibody for detection of March5 also known as Membrane-associated RING finger protein 5 & has been validated in WB, ICC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application Notes Immunocytochemistry Analysis: A representative lot of this antibody was used by an independent laboratory in IC. (Korfali, N., et al. (2010). Mol Cell Proteomics. 9:2571-2585.)
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human March5.
.
Host Rabbit
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse and rat based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Summary: March5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM].
Gene Symbol
  • MITOL
  • MARCH-V
  • RNF153
Purification Method Unpurified
UniProt Number
UniProt Summary FUNCTION: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.

PATHWAY: Protein modification; protein ubiquitination.

SUBUNIT STRUCTURE: Monomer and homodimer. Interacts with MFN1, MFN2, DNM1L and FIS1.

SUBCELLULAR LOCATION: Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note: Authors show that the protein can be detected in endoplasmic reticulum. Authors show its presence only in mitochondria.

TISSUE SPECIFICITY: Expressed in brain, heart, liver, lung, spleen, stomach, testis, skeletal and muscle.

DOMAIN: The RING-CH-type zinc finger domain is required for E3 ligase activity (by similarity).

POST-TRANSLATIONAL MODIFICATION: Autoubiquitinated leading to degradation (short half-life).

MISCELLANEOUS: By binding to and ubiquitinating two ALS1 variants of SOD1 (mSOD1 variants Arg-86 and Ala-94) it attenuates their cytotoxicity.

SEQUENCE SIMILARITIES: Contains 1 RING-CH-type zinc finger.
Molecular Weight ~52 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in HL-60 cell lysate.

Western Blot Analysis: A 1:2,000 dilution of this antibody detected March5 on 10 µg of HL-60 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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