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Anti-Clusterin a chain (human), clone 41D

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货号：05-354

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H ICC, IHC, IH(P), WB M Purified Monoclonal Antibody
Description
Catalogue Number 05-354
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Clusterin α chain (human) Antibody, clone 41D
Alternate Names
  • Apolipoprotein J
  • Complement cytolysis inhibitor
  • Complement-associated protein SP-40,40
  • Ku70-binding protein 1
  • Testosterone-repressed prostate message 2
  • aging-associated protein 4
  • clusterin
  • complement lysis inhibitor
  • complement-associated protein SP-40
  • sulfated glycoprotein 2
Background Information Clusterin is also known as apolipoprotein J, complement lysis inhibitor, gp80, glycoprotein III, SGP-2, SP 40-40, TRPM2 and T64. It is a ubiquitous multifunctional protein of 80kD comprising of two disulfide-linked subunits, alpha and beta, and capable of interacting with a broad range of molecules. It is implicated in numerous biological processes including sperm maturation, lipid transport, regulation of the complement cascade, membrane recycling, cell death, immune regulation, cell adhesion and morphological transformation. In pathological conditions, it is an amyloid associated protein co-localising with fibrillar deposits in systemic and localised amyloid disorders. In Alzheimer ’s disease, clusterin is present in amyloid plaques and cerebrovascular deposits. In breast cancers, clusterin expression was found to correlate with tumour size. Clusterin is also implicated with endometrial cancers, myocardial infarction, renal diseases and atherosclerosis.
References
Product Information
Format Purified
Control
  • HeLa cell lysate.
Presentation Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, with 0.05% sodium azide. Frozen at -20°C.
Applications
Application Anti-Clusterin α chain (human) Antibody, clone 41D is an antibody against Clusterin α chain (human) for use in IC, IH, IH(P) & WB.
Key Applications
  • Immunocytochemistry
  • Immunohistochemistry
  • Immunohistochemistry (Paraffin)
  • Western Blotting
Application Notes Immunohistochemistry:
Previous lots of this antibody at 5 µg/mL detected clusterin in paraffin embedded human brain sections.
Biological Information
Immunogen Native clusterin purified from human serum. Clone 41D.
Clone 41D
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes human clusterin α chain, Mr 40 kDa, and precursor protein.
Isotype IgG1κ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • CLU
  • SP-40
  • MGC24903
  • NA1/NA2
  • SGP-2
  • AAG4
  • KUB1
  • APOJ
  • CLI
  • TRPM-2
  • TRPM2
  • Apo-J
  • SGP2
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P10909 # Not yet clear. It is known to be expressed in a variety of tissues and it seems to be able to bind to cells, membranes and hydrophobic proteins. It has been associated with programmed cell death (apoptosis).
SIZE: 449 amino acids; 52495 Da
SUBUNIT: Antiparallel disulfide-linked heterodimer. Interacts with CLUAP1.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: SwissProt: P10909 ## Belongs to the clusterin family.
Molecular Weight 40 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated on RIPA lysates from HeLa cells or MCF-7 cell lysates.

Western Blot Analysis:
0.5-2 µg/mL of a previous lot detected human clusterin α chain in RIPA lysates from HeLa cells; previous lots detected the protein in human serum and MCF-7 cell lysates
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20°C from date of receipt.

Handling Recommendations:
Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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