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Anti-Ipaf (NLRC4) (rabbit polyclonal)

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货号：06-1125

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M ICC, WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 06-1125
Description Anti-Ipaf (NLRC4) Antibody
Alternate Names
  • NLR family, CARD domain containing 4
  • NOD-like receptor C4
  • caspase recruitment domain family, member 12
  • ICE-protease activating factor
  • nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
  • NLR family CARD domain-containing protein 4
  • Caspase recruitment domain-containing protein 12
  • Ice protease-activating factor
  • Clan protein
  • CARD, LRR, and NACHT-containing protein
Background Information Ipaf, also known as NLRC4, is a human CED-4 homologue and is thought to be an activator of pro-caspase-1 and might also be associated with the activation of caspase-1 as a response to pro-inflammatory and apoptotic stimulus. It has been shown to be induced by p53 and contributes to p53-dependent apoptosis. Ipaf is thought to play a role in the activation of the innate immune system.
References
Product Information
Format Affinity Purified
Control
  • Human lung tissue lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-Ipaf (NLRC4) Antibody is validated for use in IC, WB for the detection of Ipaf (NLRC4).
Key Applications
  • Immunocytochemistry
  • Western Blotting
Application Notes Western Blot Analysis: 1 ug/ml of this antibody detected Ipaf in 10 ug of human lung tissue lysate.

Immunocytochemistry Analysis: A 1:500 dilution from a previous lot detected Ipaf in NIH/3T3 cells.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human Ipaf (NLRC4) at the LRR4 domain.
Epitope LRR4 domain
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes Ipaf at the LRR4 domain.
Species Reactivity
  • Human
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Summary: In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM].
Gene Symbol
  • IPAF
  • CLAN
  • CARD12
  • CLAN1
  • ipaf
  • CLR2.1
  • CLAND
  • CLANA
  • CLANB
  • CLANC
  • Ipaf
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Plays a role in the promotion of apoptosis.

SUBUNIT STRUCTURE: Self-associates and binds to ASC, pro-caspase-1, NOD2, BCL10 and NALP1 (NAC) by CARD-CARD interaction.

SUBCELLULAR LOCATION: Cytoplasm. Note: Cytoplasmic filaments.

TISSUE SPECIFICITY: Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.

SEQUENCE SIMILARITIES: Contains 1 CARD domain.

Contains 14 LRR (leucine-rich) repeats.

Contains 1 NACHT domain.
Molecular Weight ~112 kDa observed.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in human lung tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Ipaf in 10 µg of human lung tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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