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Anti-NLRP13 (rabbit polyclonal)

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货号：06-1344

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R, M WB, ICC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 06-1344
Description Anti-NLRP13 Antibody
Alternate Names
  • NLR family, pyrin domain containing 13
  • Nucleotide-binding oligomerization domain protein 14
  • NACHT, leucine rich repeat and PYD containing 13
  • nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 13
  • NACHT, LRR and PYD containing protein 13
  • NACHT, LRR and PYD domains-containing protein 13
Background Information NLRP13, also known as NALP13, is a member of the NALP family of cytoplasmic proteins. NALPs have been associated with activating caspase-1 using toll-like receptors (TLRs) during the immune response. The specific function of NLRP13 is unknown.
References
Product Information
Format Affinity Purified
Control
  • C2C12 cell lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-NLRP13 Antibody detects level of NLRP13 & has been published & validated for use in WB & IC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application Notes Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected NLRP13 in NIH/3T3 cells.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human NLRP13.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Species Reactivity
  • Human
  • Rat
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Summary: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP13, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM].
Gene Symbol
  • NOD14
  • NALP13
  • PAN13
  • NLRP13
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Involved in inflammation Potential.

SEQUENCE SIMILARITIES: Belongs to the NLRP family.

Contains 1 DAPIN domain.

Contains 7 LRR (leucine-rich) repeats.

Contains 1 NACHT domain.
Molecular Weight ~119 kDa observed. An uncharacterized band appears at ~90 kDa in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in C2C12 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected NLRP13 on 10 µg of C2C12 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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