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Anti-phospho-TBC1D1 (Ser237) (rabbit polyclonal)

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货号：07-2268

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Chp, Rhesus Macaque, Ox WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 07-2268
Description Anti-phospho-TBC1D1 Antibody (Ser237)
Alternate Names
  • TBC1 domain family member 1
  • TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
Background Information TBC1D1 is the first member of a family of proteins that contain the tbc box motif of 180-220 amino acids and may be related to cell growth and differentiation. The composition of TBC1D1 has the same function as a known regulator of insulin-mediated Glut4 translocation and may play a role in severe human obesity. An insulin-independent increase in glucose transport several hours after exercise has been attributed to TBC1D1 phosphorylation. The R125W mutation of TBC1D1 is thought to decrease skeletal muscle glucose transport and could be the main reason for the obesity that seems to be linked to this type of mutation.
References
Product Information
Format Affinity Purified
Control
  • Lambda phosphatase treated and untreated HEK293 cell lysates
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This phospho-TBC1D1 antibody is validated for use in WB for the detection of the phospho-TBC1D1 protein.
Key Applications
  • Western Blotting
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human TBC1D1 phosphorylated at Ser237.
Epitope Phosphorylated Ser237
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes TBC1D1 phosphorylated at Ser237.
Species Reactivity
  • Human
  • Mouse
  • Rat
  • Chimpanzee
  • Rhesus Macaque
  • Ox
Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse, rat, chimpanzee, rhesus macaque, and ox based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied by OMIM].
Gene Symbol
  • TBC1D1
  • TBC
  • TBC1
Modifications
  • Phosphorylation
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues (By similarity).

SUBCELLULAR LOCATION: Nucleus (By similarity).

SEQUENCE SIMILARITIES: Contains 1 PID domain.

Contains 1 Rab-GAP TBC domain.

SEQUENCE CAUTION: The sequence BAB55057.1 differs from that shown. Reason: Erroneous initiation.
Molecular Weight ~145 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in lambda phosphatase treated and untreated HEK293 cell lysates.

Western Blot Analysis: 1 µg/mL of this antibody detected TBC1D1 on 10 µg of lambda phosphatase treated and untreated HEK293 cell lysates.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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