[关闭]
您好!欢迎来到炼石商城   请登录  注册    兼职小伙伴  
我的购物车
0
Qiagen 凯杰 Biosharp Omega

首页抗体Millipore 密理博>

图片仅供参考,请以实物为准
收藏

Anti-vWF (von Willebrand Factor), clone GMA-022 (mouse monoclonal IgG1)

价:
0.00
价:
¥0.00

号:05-861

牌:Millipore 密理博

账期 货到付款

EA (预计3-5工作日到货)

亲,想了解价格请QQ咨询客服!

工作时间

周一至周五:9:00-18:00

咨询电话

0771-3293894

在线咨询

客服 郭恒 蔡玉坤 曾宪飞 技术咨询

浏览了该商品的用户还浏览了

Replacement Information

重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB M Purified Monoclonal Antibody
Description
Catalogue Number 05-861
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-vWF (von Willebrand Factor) Antibody, clone GMA-022
References
Product Information
Format Purified
Applications
Application Anti-vWF (von Willebrand Factor) Antibody, clone GMA-022 is an antibody against vWF (von Willebrand Factor) for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen Purified human von Willebrand Factor
Clone GMA-022
Host Mouse
Specificity von Willebrand Factor
Isotype IgG1
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22.
Gene Symbol
  • VWF
  • F8
  • vWF
  • VWD
  • F8VWF
Purification Method DEAE purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P04275 # Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
SIZE: 2813 amino acids; 309299 Da
SUBUNIT: Multimeric. Interacts with F8.
SUBCELLULAR LOCATION: Secreted. Note=Localized to storage granules.
TISSUE SPECIFICITY: Plasma.
DOMAIN: SwissProt: P04275 The von Willebrand antigen 2 is required for multimerization of VWF and for its targeting to storage granules.
PTM: All cysteine residues are involved in intrachain or interchain disulfide bonds.
DISEASE: SwissProt: P04275 # Defects in VWF are associated with various forms of von Willebrand disease (VWD) [MIM:193400, 277480]. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.). Type I VWD is associated with a deficiency of VWF; type II by normal to decreased plasma level of VWF; type III by a virtual absence of VWF. There are subtypes (A to H) of type II VWD; for example: type IIA is characterized by the absence of VWF high molecular weight multimers in plasma.
SIMILARITY: Contains 1 CTCK (C-terminal cystine knot-like) domain. & Contains 4 TIL (trypsin inhibitory-like) domains. & Contains 3 VWFA domains. & Contains 3 VWFC domains. & Contains 4 VWFD domains.
Molecular Weight 260kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by immunoblot
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C from date of shipment
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

温馨提示:因厂家更改产品包装、产地或者更换随机附件等没有任何提前通知,且每位咨询者购买情况、提问时间等不同,为此以下回复仅对提问者3天内有效,其他网友仅供参考!若由此给您带来不便请多多谅解,谢谢!

我要咨询

咨询内容:
支付方式 货到付款 账期付款

服务热线

0771-3293894