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Anti-CTGF, C-Term (goat polyclonal)

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货号：ABS1628

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, NEUT Gt Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABS1628
Description Anti-CTGF Antibody, C-Term
Alternate Names
  • Connective tissue growth factor
  • CCN family member 2
  • Hypertrophic chondrocyte-specific protein 24
  • IBP-8
  • IGF-binding protein 8
  • IGFBP-8
  • Insulin-like growth factor-binding protein 8
Background Information Connective tissue growth factor (UniProt P29279; also known as CCN family member 2, Hypertrophic chondrocyte-specific protein 24, IBP-8, IGF-binding protein 8, IGFBP-8, Insulin-like growth factor-binding protein 8) is encoded by the CTGF (also known as CCN2, HCS24, IGFBP8) gene (Gene ID 1490) in human. CTFG is one the three founding members of the CCN (Ctgf, Cyr61, and Nov) family of proteins involved in a wide array of cellular activities, including migration, proliferation, extracellular matrix synthesis, adhesion, survival, differentiation, and apoptosis. CTGF acts an autocrine mediator of transforming growth factor-beta (TGF-beta) in fibroblasts. CCN proteins are characterized by a more than 10% cysteine content and an absolute conservation of the position of their 38 cysteine residues. Human CTGF is synthesized with a signal peptide sequence (a.a. 1-26), the removal of which yields the mature protein with an N-terminal IGF-binding protein (IGFBP) domain (a.a. 27-98), followed by a von Willebrand factor type C (VWC or VWFC) domain (a.a. 101-167), a cysteine-free hinge region (a.a. 168-197), thrombospondin type-1 (TSP-1) domain (a.a. 198-243), and a C-terminal cysteine-knot or C-terminal CYS-KNOT (CTCK) motif (a.a. 256-330). Due to the high number of disulfide bridges, most of the CTGF domains are resistant to proteolytic digestion, and most proteases primarily cleave only in the cysteine-free hinge region, producing almost exclusively intact N- and C-terminal half fragments. The N-terminal half of CTGF is shown to mediate differentiation and collagen synthesis in concert with IGF-2, while its C-terminal half mediates cell proliferation in concert with EGF.
References
Product Information
Format Affinity Purified
Presentation Purified goat polyclonal antibody in 0.3 M Glycine, 50 mM Tris, pH 8.0 without preservatives.
Applications
Application This Anti-CTGF Antibody, C-Term is validated for use in Western Blotting, Neutralizing for the detection of CTGF.
Key Applications
  • Western Blotting
  • Neutralizing
Application Notes Western Blotting Analysis: A representative lot detected the C-terminal (181-349), but not N-terminal (1-180), fragment derived from baculovirus expressed human CTGF by chymotrypsin cleavage (Grotendorst, G.R., and Duncan, M.R. (2005). FASEB J. 19(7):729-738).
Neutralizing Analysis: A representative lot inhibited CTGF-stimulated DNA synthesis, but not CTGF-stimulated collagen synthesis, in rat kidney (NRK) fibroblasts (Grotendorst, G.R., and Duncan, M.R. (2005). FASEB J. 19(7):729-738).
Note: It is recommended that gel electrophoresis be performed under non-reducing condition to effectively separate CTGF N- and C-terminal fragments, as well as differentially glycosylated N-terminal fragments.
Biological Information
Immunogen Recombinant full-length human CTGF.
Epitope C-terminal half.
Concentration Please refer to lot specific datasheet.
Host Goat
Specificity This polyclonal antibody was affinity-purified using the purified C-terminal fragment (181-349) from chymotrypsin-cleaved rhCTGF to eliminate immunoreactivity against the N-terminal half (1-180) of CTGF in the original goat antiserum raised against full-length rhCTGF (Grotendorst, G.R., and Duncan, M.R. (2005). FASEB J. 19(7):729-738).
Species Reactivity
  • Human
Species Reactivity Note Human.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • CTGF
  • CCN2
  • HCS24
  • IGFBP8
Purification Method Affinity purified.
UniProt Number
Molecular Weight 35.92/38.09 kDa (isoform Long mature/pro-form), 19.14 kDa (isoform Long C-terminal fragment; a.a. 181-349), 33.04/35.21 kDa (isoform Short mature/pro-form) calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting of chymotrypsin-cleaved CTGF fragments.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected 1 ng of the C-terminal (181-349), but not N-terminal (1-180), fragment derived from baculovirus expressed human CTGF by chymotrypsin cleavage.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size 100 μg
Transport Information
Supplemental Information
Specifications

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