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Anti-MSX2, clone 7D11.1 (mouse monoclonal)

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货号：MABD22

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R, M WB, FC M Purified Monoclonal Antibody
Description
Catalogue Number MABD22
Description Anti-MSX2 Antibody, clone 7D11.1
Alternate Names
  • Homeobox protein MSX-2
  • Homeobox protein Hox-8
Background Information MSX2, also known as HOX-8, is a homeobox containing transcription factor, which is a member of the MSH family of homeobox proteins, and is expressed at sites of epithelial-mesenchymal interaction during embryogenesis. More specifically, MSX2 has been found to be expressed in the epidermis, hair follicles, and fibroblasts of the developing fetal skin, and is detected as a diffuse cytoplasmic signal in fetal epidermis and portions of the hair follicle and dermis. In adult epidermis, however, MSX2 expression is localized to the nucleus. More recently, when in combination with another homeobox gene, MSX1, MSX2 has been shown to play a critical role in the developmental stages of both neural tube and neural crest, suggesting that both the MSX1 and the MSX2 genes play an important role in organogenesis.
References
Product Information
Format Purified
Control
  • HeLa cell lysate
Presentation Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-MSX2 Antibody, clone 7D11.1 is an antibody against MSX2 for use in WB, FC.
Key Applications
  • Western Blotting
  • Flow Cytometry
Application Notes Flow Cytometry Analysis: A previous lot of this antibody was used to detect MSX2 in HeLa cells.
Biological Information
Immunogen GST-tagged recombinant protein corresponding to human MSX2.
Clone 7D11.1
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Isotype IgG2bκ
Species Reactivity
  • Human
  • Rat
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq].
Gene Symbol
  • MSX2
  • HOX8
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.

SUBUNIT STRUCTURE: Interacts with MINT By similarity. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80).

SUBCELLULAR LOCATION: Nucleus.

INVOLVEMENT IN DISEASE: Defects in MSX2 are the cause of parietal foramina 1 (PFM1) [MIM:168500]; also known as foramina parietalia permagna (FPP). PFM1 is an autosomal dominant disease characterized by oval defects of the parietal bones caused by deficient ossification around the parietal notch, which is normally obliterated during the fifth fetal month. Defects in MSX2 are the cause of parietal foramina with cleidocranial dysplasia (PFMCCD) [MIM:168550]; also known as cleidocranial dysplasia with parietal foramina. PFMCCD combines skull defects in the form of enlarged parietal foramina and deficient ossification of the clavicles. Ref.12

Defects in MSX2 are the cause of craniosynostosis type 2 (CRS2) [MIM:604757]; also known as craniosynostosis Boston-type (CSB). CRS2 is an autosomal dominant disorder characterized by the premature fusion of calvarial sutures. The craniosynostosis phenotype is either fronto-orbital recession, or frontal bossing, or turribrachycephaly, or cloverleaf skull. Associated features include severe headache, high incidence of visual problems (myopia or hyperopia), and short first metatarsals. Intelligence is normal.

SEQUENCE SIMILARITIES: Belongs to the Msh homeobox family.

Contains 1 homeobox DNA-binding domain.
Molecular Weight ~29 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 2 µg/mL of this antibody detected MSX2 on 10 µg of HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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