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Epoxomicin Inhibitor

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货号：19-203

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 19-203
Brand Family Upstate
Trade Name
  • Upstate
Description Epoxomicin Inhibitor
References
Product Information
Applications
Application The Epoxomicin Inhibitor controls the biological activity of Epoxomicin. This small molecule/inhibitor is primarily used for Biochemicals applications.
Key Applications
  • Inhibits Activity/Function
Application Notes Cell permeable, potent and specific irreversible inhibitor of the proteasome. Novel mechanism of action. Blocks chymotrypsin-like, trypsin like and PGPH activities of the proteasome. Regulates antigen presentation at non-toxic doses. Displays in vivo anti-inflammatory activity in mouse ear inflammation assay and in vitro NF-kB inhibition. The product is not sterile.
Biological Information
Entrez Gene Number
Entrez Gene Summary This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.
Gene Symbol
  • RPS27A
  • CEP80
  • ubiquitin
  • ubiquitin-CEP80
  • UBCEP1
  • Ubiquitin.
  • UBA52
  • UBCEP2
  • UBA80
  • UBC
  • UBB
  • HUBCEP80
Protein Target RPS27A
UniProt Number
UniProt Summary FUNCTION: SwissProt: P62988 # Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair.
SIZE: 76 amino acids; 8565 Da
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
PTM: Several types of polymeric chains can be formed, depending on the lysine used for the assembly.
SIMILARITY: SwissProt: P62988 ## Belongs to the ubiquitin family.
MISCELLANEOUS: Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Store at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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