Ubiquitin C-terminalhydrolase L3 (UCH-L3) - 炼石商城

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Ubiquitin C-terminalhydrolase L3 (UCH-L3)

市场价：: 0.00

促销价：: ¥0.00

货号：14-856

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Entrez Gene Number	Species	Uni Prot Number
NM_006002.3	Human	P15374

Description
Catalogue Number	14-856
Brand Family	Upstate
Trade Name	Upstate
Description	Ubiquitin C-terminal hydrolase L3 (UCH-L3), 50 µg
Overview	Produced from human cDNA, expressed in E. coli. Ubiquitin C-terminal hydrolases (UCHs) are a family of cysteine hydrolases that catalyze the hydrolysis of amides, esters and thioesters of the C-terminus of ubiquitin. UCH-L3 is a member of the lower molecular weight group of UCHs involved in the hydrolysis of small C-terminal derivatives of ubiquitin that form non-specifically during the process of protein ubiquitinylation.

References

Product Information

Applications
Application	From human cDNA, expressed in E. coli. Ubiquitin C-terminal hydrolases are a family of cysteine hydrolases that catalyze the hydrolysis of amides, esters & thioesters of the C-terminus of ubiquitin.

Biological Information
Source	Recombinant human UCH-L3 expressed in E.coli.
Specific Activity	>1000 pmol/min/μg. Determined at 25°C with 1 μM ubiquitin-AMC as substrate and UCH-L3 at 20 pM (0.58 ng/mL).
Entrez Gene Number	NM_006002.3
Gene Symbol	UCHL3
UniProt Number	P15374
UniProt Summary	FUNCTION: SwissProt: P15374 # Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. SIZE: 230 amino acids; 26183 Da SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, and testis. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: SwissProt: P15374 # A defect or alteration in the expression of enzymes catalyzing the removal of ubiquitin from ubiquitin-proteins conjugates may be a characteristic of neurodegenerative diseases such as Alzheimer disease, Parkinson disease, progressive supranuclear palsy, and Pick and Kuf disease. & Identified as a tumor-specific antigen in colon cancer. SIMILARITY: SwissProt: P15374 ## Belongs to the peptidase C12 family.
Molecular Weight	26.2 kDa

Physicochemical Information

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Materials Information

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Safety Information according to GHS

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Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Store at -70°C for up to 12 months from date of receipt. As supplied, the enzyme is stable on ice for several hours. Activity is stable up to 6 freeze/thaw cycles (snap freezing in a dry/ice ethanol bath or liquid nitrogen).

Packaging Information
Material Size	50 µg

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