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Milli-Mark™ Anti-CD30-FITC clone Ber-H2

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货号：FCMAB192F

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H FC M FITC Monoclonal Antibody
Description
Catalogue Number FCMAB192F
Trade Name
  • Milli-Mark
Description Milli-Mark™ Anti-CD30-FITC Antibody, clone Ber-H2
Alternate Names
  • Tumor necrosis factor receptor superfamily member 8
  • CD30L receptor
  • Lymphocyte activation antigen CD30
  • Ki-1 antigen
Background Information CD30 is a transmembrane cytokine receptor belonging to the tumor necrosis factor (TNF) receptor superfamily. Mature CD30 has a molecular mass of 120 kDa and is derived from a 90 kDa precursor protein (de Bruin, 1995). The extracellular domain of CD30 is homologous to that of TNF receptor superfamily members, whereas there is no homology in teh cytoplasmic domain, suggesting major differences in signaling mechanisms (Falini, 1995). CD30 expression is found on Hodgkin and Reed-Sternberg (H-RS) cells, and on activated B and T lymphocytes (de Bruin, 1995). The antibody from the Ber-H2 hybridoma cell line was included in the Fourth International Workshop on Human Leukocyte Differentiation Antigens and was found to belong to the CD30 cluster (Schwarting, 1989).
References
Product Information
Format FITC
Control
  • Jurkat cells
Presentation Purified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.

Applications
Application Milli-Mark Anti-CD30-FITC Antibody, clone Ber-H2 detects level of CD30 & has been published & validated for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
Immunogen Co-cell line established from a human with Hodgkin's disease of T-cell lineage.
Clone Ber-H2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Antibody recognizes Human CD30 antigen.
Isotype IgG1κ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Purification Method Protein A Purfied
UniProt Number
UniProt Summary Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
Molecular Weight 120 kDa (de Bruin, 1995)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by flow cytometry using Jurkat cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size 100 tests
Transport Information
Supplemental Information
Specifications

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