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Anti-Ago4, clone 1B7-G11 (mouse monoclonal)

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货号：MABE139

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, IP M Purified Monoclonal Antibody
Description
Catalogue Number MABE139
Description Anti-human Ago4 Antibody, clone 1B7-G11
Alternate Names
  • Protein argonaute-4
  • Argonaute4
  • hAgo4
  • Eukaryotic translation initiation factor 2C 4
  • eIF-2C 4
  • eIF2C 4
Background Information AGO4 (Argonaute 4), also known as EIF2C4 is involved in regulation of gene silencing via small RNA’s such as siRNA and miRNA. This protein contains both a PAZ and a PIWI domain characteristic of Argonaute family of proteins. Functionally Ago4 is the catalytic component of the RNA-induced silencing complex (RISC). As part of this multi-protein complex, Ago4 interacts with miRNAs to help mediate translational repression of targeted messages.
References
Product Information
Format Purified
Control
  • HeLa cell lysate
Presentation Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-human Ago4 Antibody, clone 1B7-G11 is a Mouse Monoclonal Antibody for detection of human Ago4 clone 1B7-G11 also known as Protein argonaute-4, Argonaute4, hAgo4 & has been validated in WB & IP.
Key Applications
  • Western Blotting
  • Immunoprecipitation
Application Notes Immunoprecipitation Analysis: A representative lot was used by an indpendent laboratory in Jurkat and HeLa cell extract. (Azuma-Mukai, A., et al. (2008). Proc Natl Acad Sci USA. 104(23):7964-7969.)
Biological Information
Immunogen Recombinant protein corresponding to human Ago4.
Clone 1B7-G11
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Isotype IgG2aκ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1.
Gene Symbol
  • EIF2C4
  • AGO4
  • KIAA1567
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).

SUBUNIT STRUCTURE: Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B.

SUBCELLULAR LOCALIZATION: Cytoplasm › P-body

Molecular Weight ~98 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: A 1 µg/mL of this antibody detected Ago4 in 10 µg HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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