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Anti-phospho GluR1 (Thr840) (rabbit polyclonal)

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货号：AB2292

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB2292
Description Anti-phospho GluR1 (Thr840) Antibody
Alternate Names
  • AMPA 1
  • AMPA-selective glutamate receptor 1
  • Glutamate receptor ionotropic, AMPA 1
  • glutamate receptor, ionotropic, AMPA 1
Background Information Glutamate receptors (GluRs) can be categorized as ionotropic or metabotropic and subcatergorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contribute to the functional diversity of AMPA receptors. In general, AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. GluR1 is believed to mediate calcium influx, and has a vital function in synaptic plasticity related to learning. Reduction in GluR1 has been caused by FMR1 gene mutation and contributes to fragile X syndrome. Changes in expression of GluR1 receptors on dopamine neurons have been correlated with sensitization of drugs of abuse.
References
Product Information
Format Affinity Purified
Control
  • Phosphatase treated and untreated rat hippocampal P2 tissue lysates
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Applications
Application Detect phospho GluR1 (Thr840) using this Anti-phospho GluR1 (Thr840) Antibody validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen Linear peptide corresponding to rat GluR1 phosphorylated at Thr840.
Epitope Phosphorylated Thr840
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes GluR1 when phosphorylated at Thr840.
Species Reactivity
  • Rat
Species Reactivity Note Demonstrated to react with rat. Predicted to react with human and mouse based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Mouse homolog may play a role in regulation of neuronal synaptic plasticity and conditioned reinforcement learning. [RGD]
Gene Symbol
  • GLUH1
  • GLUR1
  • GLURA
  • GluR-1
  • GluR-A
  • GluR-K1
  • HBGR1
  • GRIA1
Modifications
  • Phosphorylation
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.

SUBUNIT STRUCTURE: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with CACNG2, HIP1 and probably RASGRF2.

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Note: Interaction with CACNG2 promotes cell surface expression.

TISSUE SPECIFICITY: Detected in cerebellum (at protein level).

PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis By similarity.

POLYMORPHISM: Both variants Ser-710 and Thr-710 are phosphorylated at this position.

MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.

SEQUENCE SIMILARITIES: Belongs to the glutamate-gated ion channel (TC 1.A.10) family. [View classification]
Molecular Weight ~101 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in phosphatase treated and untreated rat hippocampus P2 tissue lysates.

Western Blot Analysis: 1 µg/mL of this antibody detected GluR1 on 10 µg of phosphatase untreated rat hippocampus P2 tissue lysates while showing no reactivity on a phosphatase treated control.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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