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Anti-Integrin alpha 10 (ITGA10)

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货号：AB6030

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, Po, Rhesus Macaque, Chp, Ca, Pm WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB6030
Description Anti-Integrin alpha 10 (ITGA10) Antibody
Alternate Names
  • Integrin, alpha 10
  • integrin alpha-10
Background Information Integrins are transmembrane proteins that are involved in interactions cell-to-cell and cell-to-extracellular matrix (ECM) adhesion. Integrins play diverse roles including cell migration, development, wound healing, differentiation, and apoptosis. Integrin alpha 10 subunit (ITGA10), along with integrin beta 1, is thought to be an essential part of a novel collagen type II receptor expressed mainly in chondrocytes and cartilage tissue.
References
Product Information
Format Affinity Purified
Control
  • SW-1353 cell lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Detect Integrin alpha 10 (ITGA10) using this Anti-Integrin alpha 10 (ITGA10) Antibody validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the extracellular domain of human Integrin alpha-10.
Epitope Extracellular Domain
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes the extracellular domain of Integrin alpha 10.
Species Reactivity
  • Human
  • Pig
  • Rhesus Macaque
  • Chimpanzee
  • Canine
  • Primate
Species Reactivity Note Demonstrated to react with human.
Predicted to react with pig, rhesus monkey, chimpanzee, and canine based on 100% sequence homology.
Other homologies: rat (93% sequence homology).
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Summary: Integrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue. [provided by RefSeq].
Gene Symbol
  • PRO827
  • ITGA10
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Integrin alpha-10/beta-1 is a receptor for collagen.

SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Alpha-10 associates with beta-1.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

TISSUE SPECIFICITY: Widely expressed with highest expression in muscle and heart. Found in articular cartilage.

DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

SEQUENCE SIMILARITIES: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. Contains 1 VWFA domain.
Molecular Weight ~127 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in SW-1353 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected integrin alpha10 in 10 µg of SW-1353 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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