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Anti-P/CAF (rabbit polyclonal)

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货号：AB9962

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Mk WB, ICC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB9962
Description Anti-P/CAF Antibody
Alternate Names
  • K(lysine) acetyltransferase 2B
  • P300/CBP-associated factor
  • Histone acetyltransferase PCAF
  • histone acetyltransferase KAT2B
  • Lysine acetyltransferase 2B
  • Histone acetylase PCAF
  • CREBBP-associated factor
Background Information P/CAF(sometimes called KAT2B) is a transcription cofactor with a histone acetyltransferase (HAT) activity. Consistent with this protein playing a direct role in transcriptional regulation, P/CAF can acetylate core histones H3 and H4, chromatin proteins HMG17 and HMG I(Y), as well as human immunodeficiency virus Tat, transcription factor MyoD, and general transcription factors TFIIE and TFIIF. A role for P/CAF in cell growth and differentiation is suggested by its interaction in vivo and in vitro with p300/CBP, two large nuclear proteins that bind to sequence-specific factors involved in cell growth/differentiation. A role for P/CAF in cell division is also suggested by data showing that this protein competes with E1A for binding sites in p300/CBP to counteract E1A's mitogenic activity.
References
Product Information
Format Affinity Purified
Control
  • HeLa nuclear extract
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-P/CAF Antibody is a Rabbit Polyclonal Antibody for detection of P/CAF also known as K(lysine) acetyltransferase 2B, P300/CBP-associated factor & has been validated in WB, ICC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application Notes Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected P/CAF in HeLa cells.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the C-terminus of P/CAF.
Epitope C-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes P/CAF at the C-terminus.
Species Reactivity
  • Human
  • Mouse
  • Rat
  • Monkey
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Summary: CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq].
Gene Symbol
  • GCN5
  • GCN5L
  • P/CAF
  • P
  • CAF
  • PCAF
  • KAT2B
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.

CATALYTIC ACTIVITY: Acetyl-CoA + [histone] = CoA + acetyl-[histone].

SUBUNIT STRUCTURE: Interacts with SIRT1. Interacts (unsumoylated form) with NR2C1; the interaction promotes tranactivation activity (By similarity). Interacts with EP300 and CREBBP. Interacts with NCOA1 and NCOA3. Component of a large chromatin remodeling complex, at least composed of MYSM1, KAT2B/PCAF, RBM10 and KIF11/TRIP5. Interacts with NR2C2 (hypophosphorylated and unsumoylated form); the interaction promotes the transactivation activity of NR2C2. Binds to HTLV-1 Tax. Interacts with and acetylates HIV-1 Tat. Interacts with KLF1; the interaction does not acetylate KLF1 and there is no enhancement of its transactivational activity. Interacts with NFE4. Interacts with MECOM.

SUBCELLULAR LOCATION: Nucleus (By similarity).

TISSUE SPECIFICITY: Ubiquitously expressed but most abundant in heart and skeletal muscle.

DOMAIN: The bromodomain mediates binding to HIV-1 Tat.

SEQUENCE SIMILARITIES: Belongs to the GCN5 family. Contains 1 bromo domain.Contains 1 N-acetyltransferase domain.
Molecular Weight ~93 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in HeLa nuclear extract.

Western Blot Analysis: 1 µg/mL of this antibody detected P/CAF on 10 µg of HeLa nuclear extract.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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