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Anti-Goosecoid (GSC) (rabbit polyclonal)

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货号：ABD15

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, Po, R, Chp, Rhesus Macaque WB, IH(P) Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABD15
Description Anti-Goosecoid (GSC) Antibody
Alternate Names
  • goosecoid homeobox
  • homeobox protein goosecoid
Background Information Homeobox protein goosecoid (GSC) has been shown to affect neuronal differentiation by slowing down the cell cycle and by up-regulating neurite outgrowth. GSC is thought to be important in the Spemann’s organizer by repressing Xwnt8 and promoting head organizer action. High levels of GSC have been found in human tumors and research has shown that GSC does advance tumor cell malignancy. Recently, a Wwp2-GSC pathway has been identified that may be useful in discouraging craniofacial abnormalities.
References
Product Information
Format Affinity Purified
Control
  • Human colon tissue lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-Goosecoid (GSC) Antibody is validated for use in WB, IH(P) for the detection of Goosecoid (GSC).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application Notes Immunohistochemistry Analysis: 1:1,000 dilution from a previous lot detected Goosecoid in normal human colon and human colon cancer tissues.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human Goosecoid near the C-terminus.
Epitope Near C-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes Goosecoid near the C-terminus.
Species Reactivity
  • Human
  • Pig
  • Rat
  • Chimpanzee
  • Rhesus Macaque
Species Reactivity Note Demonstrated to react with human. Predicted to react with pig, rat, chimpanzee, and rhesus monkey based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq].
Gene Symbol
  • GSC
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity).

SUBCELLULAR LOCATION: Nucleus.

SEQUENCE SIMILARITIES: Belongs to the paired homeobox family. Bicoid subfamily.

Contains 1 homeobox DNA-binding domain.
Molecular Weight ~28 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in human colon tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Goosecoid on 10 µg of human colon tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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