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Anti-JARID1B (rabbit polyclonal)

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货号：ABE239

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, IP Rb Serum Polyclonal Antibody
Description
Catalogue Number ABE239
Description Anti-JARID1B Antibody
Alternate Names
  • JMJD
  • lysine (K)-specific demethylase 5B
  • Jumonji, AT rich interactive domain 1B (RBP2-like)
  • putative DNA/chromatin binding motif
  • jumonji, AT rich interactive domain 1B
  • Histone demethylase JARID1B
  • retinoblastoma-binding protein 2, homolog 1A
  • Cancer/testis antigen 31
  • Jumonji/ARID domain-containing protein 1B
  • lysine-specific demethylase 5B
  • Retinoblastoma-binding protein 2 homolog 1
Background Information JARID1B (jumonji AT rich interactive domain 1B), also known as KDM5B, is histone demethylase with a preference for mono, di, and trimethylated lysine 4 of histone H3. Demethylation of lysine 4 in histone 3 is commonly associated with transcriptional repression. This nuclear protein belongs to the ARID family of DNA binding proteins and is highly expressed in a large number of breast cancers. This protein has been linked to the repressinion of multiple tumor suppressor genes including BRCA1 and HOXA5.
References
Product Information
Format Serum
Control
  • A431 cell lysate
Presentation Rabbit polyclonal serum containing 0.05% sodium azide.
Applications
Application Anti-JARID1B Antibody is a Rabbit Polyclonal Antibody for detection of JARID1B also known as lysine (K)-specific demethylase 5B & has been validated in WB & IP.
Key Applications
  • Western Blotting
  • Immunoprecipitation
Application Notes Immunoprecipitation:
A representative lot of this antibody was reported to work for immunoprecipitation analysis in Saos-2, MCF-7, and T47D lysates (Laboratory of E. Benevolenskaya , University of Illinois at Chicago).
Biological Information
Immunogen GST-tagged recombinant protein corresponding to human JARID1B at the C-terminal domain.
Epitope C-terminal domain
Host Rabbit
Specificity This antibody recognizes JARID1B at the C-terminal domain.
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • CT31
  • PLU-1
  • RBBP2H1A
  • PLU1
  • JARID1B
  • RBP2-like
  • RBP2-H1
  • PUT1
  • RBBP2H1
  • KDM5B
Purification Method Unpurified
UniProt Number
UniProt Summary FUNCTION: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.

COFACTOR: Binds 1 Fe2+ ion per subunit (By similarity).

SUBUNIT STRUCTURE: Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7 (By similarity).

SUBCELLULAR LOCATION: Nucleus

TISSUE SPECIFICTY: Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level). DOMAIN: Both the JmjC domain and the JmjN domain are required for enzymatic activity.

The 2 first PHD-type zinc finger domains are required for transcription repression activity.

SEQUENCE SIMILARITIES: Belongs to the JARID1 histone demethylase family.

Contains 1 ARID domain.

Contains 1 JmjC domain.

Contains 1 JmjN domain.

Contains 3 PHD-type zinc fingers.

SEQUENCE CAUTION: The sequence CAB63108.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
Molecular Weight ~180 kDa observed. Uncharacterized bands may be observed at ~ 48 and 53 kDa in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in A431 cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected JARID1B on 10 µg of A431 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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