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SHP-1 125UG

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货号：14-591M

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-591M
Brand Family Upstate
Trade Name
  • Upstate
Description SHP-1 Protein, 125 µg
Overview N-terminal GST-tagged recombinant human full-length SHP-1
References
Product Information
Applications
Application N-terminal GST-tagged recombinant human full-length SHP-1, for use in Phosphatase Assays.
Key Applications
  • Phosphatase Assay
Biological Information
Source expressed in E. coli
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
Gene Symbol
  • PTPN6
  • SHP-1L
  • HCP
  • SH-PTP1
  • PTP1C
  • PTP-1C
  • HCPH
  • SHP1
  • SHP-1
  • HPTP1C
Protein Target SHP-1
Purification Method Glutathione-agarose
Target Sub-Family Tyr phosphatase
UniProt Number
UniProt Summary FUNCTION: SwissProt: P29350 # Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
SIZE: 595 amino acids; 67561 Da
SUBUNIT: Monomer. Interacts with MTUS1 (By similarity). Binds PTPNS1, LILRB1 and LILRB2. Interacts with FCRL2, CD300LF and CD84.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity).
TISSUE SPECIFICITY: Isoform 1 is expressed in hematopoietic cells while isoform 2 is expressed in non-hematopoietic cells.
PTM: Phosphorylated on serine and tyrosine residues.
SIMILARITY: SwissProt: P29350 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. & Contains 2 SH2 domains. & Contains 1 tyrosine-protein phosphatase domain.
Molecular Weight 95kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by dephosphorylation of 100mM DiFMUP
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -70°C
Packaging Information
Material Size 125 µg
Material Package Also available in 10 μg size (cat#14-591) and in bulk (cat# 14-591-K).
Transport Information
Supplemental Information
Specifications

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