Anti-Thyroid Hormone Receptor ß-1 (rabbit polyclonal)

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M, R	WB	Rb	Affinity Purified	Polyclonal Antibody

Species Reactivity

Key Applications

Host

Format

Antibody Type

H, M, R

Affinity Purified

Polyclonal Antibody

Description
Catalogue Number	ABN25
Description	Anti-Thyroid Hormone Receptor β-1 Antibody
Alternate Names	Thyroid hormone receptor beta Nuclear receptor subfamily 1 group A member 2 c-erbA-2 c-erbA-beta
Background Information	Thyroid hormone receptor β-1 operates as a hormone-dependent transcriptional regulator that binds DNA sequences and is activated by 3,5,3’-l-triiodothyronine (T3). Thyroid hormone receptor β-1 is important in vertebrate development, specifically in developing limbs and face. 9-cis-retinoic acid receptor (RXR) and retinoic acid receptor (RAR) receptor families are often associated with thyroid hormone receptor β-1 and form homodimers and heterodimers. Mutations in thyroid hormone receptor β-1 have been associated with general resistance to thyroid hormones which tend to cause significant behavioral abnormalities. Recent research has linked thyroid hormone receptor β-1 to tumor suppression, where the receptor has commonly been found to be disrupted in the occurrence of cancer.

Description

Catalogue Number

ABN25

Description

Anti-Thyroid Hormone Receptor β-1 Antibody

Alternate Names

Thyroid hormone receptor beta
Nuclear receptor subfamily 1 group A member 2
c-erbA-2
c-erbA-beta

Background Information

Thyroid hormone receptor β-1 operates as a hormone-dependent transcriptional regulator that binds DNA sequences and is activated by 3,5,3’-l-triiodothyronine (T3). Thyroid hormone receptor β-1 is important in vertebrate development, specifically in developing limbs and face. 9-cis-retinoic acid receptor (RXR) and retinoic acid receptor (RAR) receptor families are often associated with thyroid hormone receptor β-1 and form homodimers and heterodimers. Mutations in thyroid hormone receptor β-1 have been associated with general resistance to thyroid hormones which tend to cause significant behavioral abnormalities. Recent research has linked thyroid hormone receptor β-1 to tumor suppression, where the receptor has commonly been found to be disrupted in the occurrence of cancer.

Product Information
Format	Affinity Purified
Control	HeLa nuclear extract
Presentation	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Product Information

Format

Affinity Purified

Control

HeLa nuclear extract

Presentation

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Applications
Application	Anti-Thyroid Hormone Receptor β-1 Antibody is a rabbit polyclonal antibody for detection of Thyroid Hormone Receptor β-1 also known as Thyroid hormone receptor beta, c-erbA-2, c-erbA-beta & has been validated in WB.
Key Applications	Western Blotting

Applications

Application

Anti-Thyroid Hormone Receptor β-1 Antibody is a rabbit polyclonal antibody for detection of Thyroid Hormone Receptor β-1 also known as Thyroid hormone receptor beta, c-erbA-2, c-erbA-beta & has been validated in WB.

Key Applications

Western Blotting

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to human Thyroid Hormone receptor β-1.
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Species Reactivity	Human Mouse Rat
Species Reactivity Note	Demonstrated to react with human and mouse. Predicted to react with rat based on 100% sequence homology.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_000452
Entrez Gene Summary	The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq].
Gene Symbol	THRB ERBA2 NR1A2 THR1
Purification Method	Affinity Purfied
UniProt Number	P10828
UniProt Summary	FUNCTION: High affinity receptor for triiodothyronine.\| P37243 # High affinity receptor for triiodothyronine. SIZE: 461 amino acids; 52788 Da SUBUNIT: Interacts with NOCA7 in a ligand-inducible manner. SUBCELLULAR LOCATION: Nucleus. DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain. DISEASE: Defects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit- hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). & Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also called familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.\| P37243 # Defects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit- hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). & Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also called familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established. SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
Molecular Weight	~60 kDa observed. An uncharacterized band may be observed at ~45 kDa in some lysates.

Biological Information

Immunogen

KLH-conjugated linear peptide corresponding to human Thyroid Hormone receptor β-1.

Concentration

Please refer to the Certificate of Analysis for the lot-specific concentration.

Host

Rabbit

Species Reactivity

Human
Mouse
Rat

Species Reactivity Note

Demonstrated to react with human and mouse. Predicted to react with rat based on 100% sequence homology.

Antibody Type

Polyclonal Antibody

Entrez Gene Number

NP_000452

Entrez Gene Summary

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq].

Gene Symbol

THRB
ERBA2
NR1A2
THR1

Purification Method

Affinity Purfied

UniProt Number

P10828

UniProt Summary

FUNCTION: High affinity receptor for triiodothyronine.| P37243 # High affinity receptor for triiodothyronine.

SIZE: 461 amino acids; 52788 Da

SUBUNIT: Interacts with NOCA7 in a ligand-inducible manner.

SUBCELLULAR LOCATION: Nucleus.

DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.

DISEASE: Defects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit- hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). & Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also called familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.| P37243 # Defects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit- hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). & Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also called familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.

SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.

Molecular Weight

~60 kDa observed. An uncharacterized band may be observed at ~45 kDa in some lysates.

Product Usage Statements
Quality Assurance	Evaluated by Western Blot in HeLa nuclear extract. Western Blot Analysis: 0.5 µg/mL of this antibody detected Thyroid Hormone receptor β-1 on 10 µg of HeLa nuclear extract.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Product Usage Statements

Quality Assurance

Evaluated by Western Blot in HeLa nuclear extract.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Thyroid Hormone receptor β-1 on 10 µg of HeLa nuclear extract.

Usage Statement

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Storage and Shipping Information

Storage Conditions

Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Packaging Information

Material Size

100 µg

实验耗材

分子生物学试剂

蛋白与免疫学

生化试剂

细胞及检测试剂

色谱及层析

仪器设备

实验服务

办公用品

Anti-Thyroid Hormone Receptor ß-1 (rabbit polyclonal)

浏览了该商品的用户最终购买

浏览了该商品的用户还浏览了

特卖

重要规格表

我要咨询