Anti-10-formyltetrahydrofolate dehydrogenase (rabbit polyclonal) - 炼石商城

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Anti-10-formyltetrahydrofolate dehydrogenase (rabbit polyclonal)

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货号：ABN57

品牌：Millipore 密理博

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
R	WB	Rb	Serum	Polyclonal Antibody

Description
Catalogue Number	ABN57
Description	Anti-10-formyltetrahydrofolate dehydrogenase Antibody
Alternate Names	aldehyde dehydrogenase 1 family, member L1 formyltetrahydrofolate dehydrogenase cytosolic 10-formyltetrahydrofolate dehydrogenase Aldehyde dehydrogenase family 1 member L1 10-formyltetrahydrofolate dehydrogenase
Background Information	10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) is also known as aldehyde dehydrogenase family 1 member L1 (ALDH1L1). 10-FTHFDH is a multidomain protein that is found in liver cytosol. It is comprised of two functionally unrelated domains, an aldehyde dehydrogenase-homologous domain and a folate-binding hydrolase domain. These two domains are thought to be connected by a 100-residue linker. 10-FTHFDH is known to induce phosphorylation of p53 at Ser6, which is a critical step in stimulating apoptosis. This process seems to be taken care of using JNK1 and JNK2.

References

Product Information
Format	Serum
Control	Rat liver tissue lysate.
Presentation	Rabbit polyclonal serum containing 0.05% sodium azide.

Applications
Application	Anti-10-formyltetrahydrofolate dehydrogenase Antibody is an antibody against 10-formyltetrahydrofolate dehydrogenase for use in WB.
Key Applications	Western Blotting

Biological Information
Immunogen	Recombinant protein corresponding to rat 10-formyltetrahydrofolate dehydrogenase.
Host	Rabbit
Species Reactivity	Rat
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_071992
Entrez Gene Summary	Summary: Catalyzes the NADP dependent oxidation of 10-HCO-H4PteGlu to H4PteGlu and Co2 [RGD].
Gene Symbol	10-fTHF FTHFD 10-FTHFDH
Purification Method	Unpurified
UniProt Number	P28037
UniProt Summary	CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH. SUBUNIT STRUCTURE: Homotetramer. SUBCELLULAR LOCATION: Cytoplasm. SEQUENCE SIMILARITIES: In the N-terminal section; belongs to the GART family. In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. Contains 1 acyl carrier domain. CAUTION: The phosphoserine observed at Ser-354 undoubtedly results from the secondary neutral loss of pantetheine from the phosphodiester linked cofactor.
Molecular Weight	~100 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blot in rat liver tissue lysate. Western Blot Analysis: A 1:1,000 dilution of this antibody detected 10-formyltetrahydrofolate dehydrogenase on 10 µg of rat liver tissue lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µL

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