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Anti-Tryptophan hydroxylase 2 (rabbit polyclonal)

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货号：ABN60

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R, H, M WB, IH(P) Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABN60
Description Anti-Tryptophan hydroxylase 2 Antibody
Alternate Names
  • tryptophan hydroxylase 2
  • Tryptophan 5-monooxygenase 2
  • Neuronal tryptophan hydroxylase
  • tryptophan 5-hydroxylase 2
Background Information Tryptophan hydroxylase 2 (TPH2) is preferentially expressed in the brain and is thought to play an important role in serotonin synthesis. Recent research has actually associated high levels of TPH2 with risk of suicide. Misfolding of TPH2 may be the cause of a loss of serotonin neuronal function in Parkinson’s disease. Detection and screening of particular mutations in TPH2 has been cited as an approach toward predicting patient sensitivity to potential antidepressant therapies and even the possibility of diagnosis of behavioral disorders.
References
Product Information
Format Affinity Purified
Control
  • Rat brain tissue lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Tryptophan hydroxylase 2 Antibody detects level of Tryptophan hydroxylase 2 & has been published & validated for use in WB, IH(P).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application Notes Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected Tryptophan hydroxylase 2 in rat cerebral cortex tissue.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human Tryptophan hydroxylase 2.
Host Rabbit
Species Reactivity
  • Rat
  • Human
  • Mouse
Species Reactivity Note Demonstrated to react with rat and human. Predicted to react with mouse based on immunogen design.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • NTPH
  • FLJ37295
  • ADHD7
  • MGC138871
  • MGC138872
  • EC 1.14.16.4
Purification Method Affinity Purfied
UniProt Number
UniProt Summary CATALYTIC ACTIVITY: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.
COFACTOR: Fe2+ ion By similarity.
PATHWAY: Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
TISSUE SPECIFICITY: Brain specific.
INVOLVEMENT IN DISEASE: Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].
Defects in TPH2 are the cause of susceptibility to attention deficit-hyperactivity disorder type 7 (ADHD7) [MIM:613003]. ADHD is a neurobehavioral developmental disorder and is primarily characterized by the co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. Note=Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.
SEQUENCE SIMILARITIES: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Contains 1 ACT domain.
BIOPHYSICOHEMICAL PROPERTIES: Kinetic parameters:
KM=41.3 µM for L-tryptophan
Vmax=833 nmol/min/mg enzyme
Molecular Weight ~56 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in rat brain tissue lysate.
Western Blotting Analysis: 0.2 µg/mL of this antibody detected Tryptophan hydroxylase 2 on 10 µg of rat brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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