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Anti-nitro-a/ß-Synuclein, clone nSyn12

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货号：36-011

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, IHC M Unpurified Monoclonal Antibody
Description
Catalogue Number 36-011
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-nitro-α/β-Synuclein Antibody, clone nSyn12
References
Product Information
Components
  • Ascites
Format Unpurified
Presentation ascites with 0.05% sodium azide
Applications
Application Anti-nitro-α/β-Synuclein Antibody, clone nSyn12 is an antibody against nitro-α/β-Synuclein for use in WB, IH.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Biological Information
Immunogen full-length recombinant human α-Synuclein nitrated in vitro
Clone clone nSyn12
Host Mouse
Specificity α-Synuclein nitrated at Tyr125 and Tyr136
β-Synuclein nitrated at Tyr130
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene.
Gene Symbol
  • SNCA
  • MGC110988
  • PD1
  • alpha-synuclein
  • NACP
  • PARK1
  • PARK4
  • Alpha-synuclein
Modifications
  • Nitration
Purification Method Ascites
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q16143 # Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6 hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
SIZE: 134 amino acids; 14288 Da
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
PTM: Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
DISEASE: SwissProt: Q16143 # Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.
SIMILARITY: SwissProt: Q16143 ## Belongs to the synuclein family.
Molecular Weight α-Synuclein, Mr 14.5kDa
β-Synuclein, Mr 17kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance rountinely evaluated on recombinant protein nitrated in vitro
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µL
Transport Information
Supplemental Information
Specifications

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