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Anti-MNBH (rabbit polyclonal)

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货号：ABS26

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABS26
Description Anti-MNBH Antibody
Alternate Names
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
  • dual specificity tyrosine-phosphorylation-regulated kinase 1A
  • mnb protein kinase homolog hp86
  • Dual specificity YAK1-related kinase
  • serine/threonine kinase MNB
  • Protein kinase minibrain homolog
  • MNB/DYRK protein kinase
  • serine/threonine-specific protein kinase
  • dual-specificity tyrosine-Y-phosphorylation regulated kinase, EC 2.7.19
Background Information Minibrain (MNBH) is also known as DYRK1 and is the human homolog of the mnb gene in Drosophila and is mapped on human chromosome 21q22.2, which is within the down syndrome critical region. MNBH may be involved in the signaling pathway that controls cell proliferation and is thought to regulate neuronal differentiation and apoptosis by phosphorylating Hip-1.
References
Product Information
Format Affinity Purified
Control
  • NIH/3T3 cell lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-MNBH Antibody is an antibody against MNBH for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen GST-tagged recombinant protein corresponding to the N-terminus of human MNBH.
Epitope N-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes MNBH at the N-terminus.
Species Reactivity
  • Human
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq].
Gene Symbol
  • DYRK1A
  • HP86
  • DYRK
  • DYRK1
  • MNBH
  • hMNB
  • MNB
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

ENZYME REGULATION: Inhibited by RANBP9.

SUBUNIT STRUCTURE; Interacts RAD54L2/ARIP4 (By similarity). Interacts with RANBP9. Interacts with WDR68.

SUBCELLULAR LOCATION: Nucleus speckle.

TISSUE SPECIFICITY: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.

DEVELOPMENTAL STAGE: Expressed in the developing central nervous system. Overexpressed 1.5-fold in fetal Down syndrome brain.

PTM: Autophosphorylated on tyrosine residues.

SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

Contains 1 protein kinase domain.
Molecular Weight ~86 kDa observed. Uncharacterized bands may be observed in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in NIH/3T3 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected MNBH on 10 µg of NIH/3T3 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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