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Anti-MMP-8 (Hinge Region) (rabbit polyclonal)

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货号：ABT38

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M, R, H WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABD38
Description Anti-SNAI1 (Snail homolog 1) Antibody
Alternate Names
  • Zinc finger protein SNAI1
  • Protein snail homolog 1
  • Protein sna
Background Information SNAI1, also known as Snail homolog 1, is a transcription factor that down regulates the expression of ectodermal genes within the mesoderm and is thought to be essential for mesoderm formation in the developing embryo. SNAI1 is expressed in the kidney and in mesenchymal and epithelial cell lines. Mutations in SNAI1 have been associated with tumors.
References
Product Information
Format Affinity Purified
Control
  • Rat brain tissue lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-SNAI1 (Snail homolog 1) Antibody is a Rabbit Polyclonal Antibody for detection of SNAI1 also known as Zinc finger protein SNAI1, Snail homolog 1 & has been validated in WB.
Key Applications
  • Western Blotting
Application Notes Western Blot Analysis: 1 µg/mL from a representative lot detected SNAI1 on 10 µg of mouse brain tissue lysate.
Biological Information
Immunogen Linear peptide corresponding to human SNAI1.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Species Reactivity
  • Mouse
  • Rat
  • Human
Species Reactivity Note Demonstrated to react with Mouse and Rat. Predicted to react with Human based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008].
Gene Symbol
  • SNAI1
  • SNAH
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Involved in the epithelial to mesenchymal transition (EMT) and formation and maintenance of embryonic mesoderm (By similarity). Binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription.

SUBUNIT STRUCTURE: Interacts with FBXL14 and GSK3B. Interacts with BTRC; interaction occurs when it is phosphorylated on the destruction motif.

SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.

TISSUE SPECIFICITY: Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.

PTM: Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for BTRC ubiquitination.

Ubiquitinated on Lys-98, Lys-137 and Lys-146 by FBXL14 and BTRC leading to degradation. BTRC-triggered ubiquitination requires previous GSK3B-mediated SNAI1 phosphorylation.

SEQUENCE SIMILARITIES: Belongs to the snail C2H2-type zinc-finger protein family.

Contains 4 C2H2-type zinc fingers.
Molecular Weight ~29 kDa observed. An uncharacterized band appears at ~40 kDa in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in rat brain tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected SNAI1 on 10 µg of rat brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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