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Anti-DNMT3A2 (rabbit polyclonal)

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货号：07-2050

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H ICC, ELISA, WB Rb Purified Polyclonal Antibody
Description
Catalogue Number 07-2050
Description Anti-DNMT3A2 Antibody
Alternate Names
  • DNA (cytosine-5-)-methyltransferase 3 alpha
  • DNA MTase HsaIIIA
  • DNA cytosine methyltransferase 3 alpha
  • DNA cytosine methyltransferase 3A2
  • DNA methyltransferase HsaIIIA
Background Information CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. DNMT3 is a developmentally regulated DNA methyltransferase. DNMT3A2 is a second isoform of DNMT3 that is expressed from an alternative promoter. DNMT3A2 localizes to euchromatin and is thought to function in de novo methylation, rather than maintenance methylation. Binding of DNMT3L (DNMT3-like protein) to DNMT3A2 promotes a dramatic reorganization of DNMT3A2 subunits and leads to the formation of specific complexes with enhanced DNA methyltransferase activity. DNMT3A2 targets endogenous DNMT3L to embryonic stem cell chromatin and induces regional DNA methylation.
References
Product Information
Format Purified
Control
  • L6, NIH/3T3, HeLa, or A431 cells.
Presentation Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Applications
Application Use Anti-DNMT3A2 Antibody (Rabbit Polyclonal Antibody) validated in ICC, ELISA, WB to detect DNMT3A2 Antibody also known as DNA (cytosine-5)-methyltransferase 3 alpha.
Key Applications
  • Immunocytochemistry
  • ELISA
  • Western Blotting
Application Notes ELISA:
This antibody was shown by an outside laboratory to be suitable for ELISA.

Immunocytochemistry:
This antibody detects DMNT3A2 in the nuclei of NIH/3T3, HeLa, and A431 cells.
Biological Information
Immunogen The immunogen was a KLH-conjugated synthetic peptide corresponding to the C-terminal region of human DNMT3A2.
Epitope C-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity The antibody recognizes isoform 2 of human DNMT3A. Additional lower molecular weight bands are detected in some samples.
Species Reactivity
  • Human
Species Reactivity Note Demonstrated to react with Human. Other homologies: Predicted to react with Mouse and Rat based on 100% sequence homology
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Gene Symbol
  • DNMT3A2
  • Dnmt3a
  • EC 2.1.1.37
  • M.HsaIIIA
  • OTTHUMP00000120005
  • OTTHUMP00000120006
Modifications
  • Methylation
Purification Method Protein A chromatography
UniProt Number
UniProt Summary FUNCTION:Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones. Ref.10

Catalytic activity S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

SUBUNIT STRUCTURE: Binds the ZNF238 transcriptional repressor. Interacts with SETDB1. Associates with HDAC1 through its ADD-type zinc-finger By similarity. Interacts with DNMT1 and DNMT3B. Interacts with the PRC2/EED-EZH2 complex.

SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Ref.3

TISSUE SPECIFICITY: Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung. Ref.7

Sequence similarities Belongs to the C5-methyltransferase family.

Contains 1 ADD-type zinc finger.

Contains 1 PWWP domain.

CAUTION:It is uncertain whether Met-1 or Met-4 is the initiator
Molecular Weight ~80 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Western Blot Analysis: 1:1,000 dilution of this antibody detected DNMT3A2 on 10 µg of L6 lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial to pellet the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size 400 µL
Transport Information
Supplemental Information
Specifications

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