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Anti-Synaptophysin, clone SY38, Alexa Fluor® 488 Conjugate

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货号：MAB5258A4

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M, H IHC M AlexaFluor®488 Monoclonal Antibody
Description
Catalogue Number MAB5258A4
Description Anti-Synaptophysin Antibody, clone SY38, Alexa Fluor® 488 Conjugate
Alternate Names
  • Synaptophysin
  • Major synaptic vesicle protein p38
Background Information Synaptophysin is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38 kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. The localization and ubiquitous expression of this protein in neuronal tissue makes it an excellent marker for neurons and neuroendocrine tumors. The gene for this protein is located on the X chromosome (Xp11.23-p11.22). The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally.
References
Product Information
Format AlexaFluor®488
Control
  • Adult mouse brain tissue
Presentation Purified mouse monoclonal IgG1κ conjugated to Alexa Fluor® 488 in buffer containing 15 mg/ml BSA with 0.1% sodium azide.
Applications
Application Anti-Synaptophysin Antibody, clone SY38, Alexa Fluor 488 Conjugate detects level of Synaptophysin & has been published & validated for use in IH.
Key Applications
  • Immunohistochemistry
Biological Information
Immunogen Vesicular fraction of bovine brain
Clone SY38
Host Mouse
Specificity This antibody reacts with presynaptic vesicles of cerebral and spinal neurons, of neuromuscular endplates and with the retina of man, cow, rat and mouse. It also reacts with vesicles of adrenal medulla and islet cells.
Isotype IgG1
Species Reactivity
  • Mouse
  • Human
Species Reactivity Note Demonstrated to react with Mouse. Predicted to react with Bovine based on immunogen design. Uncongugated antibody (MAB5258) is shown to work on Rat.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Synaptophysin (p38) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells.[supplied by OMIM]
Gene Symbol
  • SYP
Purification Method Protein G Purfied
UniProt Number
UniProt Summary FUNCTION: Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.

SIZE: 313 amino acids; 33845 Da

SUBUNIT: Homohexamer or homotetramer.

SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.

TISSUE SPECIFICITY: Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.

DOMAIN: The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.

PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (By similarity).

SIMILARITY: Belongs to the synaptophysin/synaptobrevin family. & Contains 1 MARVEL domain.
Molecular Weight The unconjugated parent antibody (Cat. No. MAB5258) has an observed molecular weight at ~38 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Immunohistochemistry in adult mouse brain tissue.

Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Synaptophysin in adult mouse brain tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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