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Anti-IL-8R (CXCR2), clone RII115 (mouse monoclonal)

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货号：MABF101

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H FC M Purified Monoclonal Antibody
Description
Catalogue Number MABF101
Description Anti-IL-8R (CXCR2) Antibody, clone RII115
Alternate Names
  • C-X-C chemokine receptor type 2
  • CXC-R2
  • CXCR-2
  • CDw128b
  • GRO/MGSA receptor
  • High affinity interleukin-8 receptor B
  • IL-8R B
  • IL-8 receptor type 2
  • CD182
Background Information Interleukin 8 Receptor beta (IL-8R), also known as CXCR2, is a type of G-protein coupled receptor and binds to interleukin 8 with high affinity to tranduce the signal thorugh a G-protein activated secondary messenger system. Knockout studies shows IL-8R alleviates both replicative and oncogene-induced senescence and diminishes the DNA-damage response. Ectopic expression results in premature senescence through a p53-dependent mechanism.
References
Product Information
Format Purified
Control
  • Human neutrophils
Presentation Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-IL-8R (CXCR2) Antibody, clone RII115 detects level of IL-8R (CXCR2) & has been published & validated for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
Immunogen Linear peptide corresponding to human IL-8R.
Clone RII115
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Isotype IgG2bκ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq].
Gene Symbol
  • CXCR2
  • IL8RB
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.

PTM: Phosphorylated upon ligand binding; which is required for desensitization.

SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 1 family.
Molecular Weight 41 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Flow Cytometry in human neutrophils.

Flow Cytometry Analysis: 0.5 µg of this antibody detected IL-8R in human neutrophils.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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