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Anti-Tim3, clone 2E2 (mouse monoclonal)

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货号：MABF62

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, FC M Purified Monoclonal Antibody
Description
Catalogue Number MABF62
Description Anti-Tim3 Antibody, clone 2E2
Alternate Names
  • Hepatitis A virus cellular receptor 2 homolog
  • T-cell immunoglobulin and mucin domain-containing protein 3
  • T-cell membrane protein 3
  • TIMD-3
  • TIM-3
Background Information As a member of the T cell immunoglobulin and mucin domain (TIM) family, Tim-3 is reported to promote or terminate Th1 immunity and is thought to influence a range of inflammatory conditions. It is constitutively expressed in a subset of murine IFNgamma-secreting Th1 cells, but not Th2 cells, in both human and mice. Additionally, Tim-3 is expressed dendritic cells, and by a subset of CD4+ cells where its levels of expression increase upon anti-CD3/28 stimulation. This molecule is also highly expressed in in vitro polarized Th1 cells, and at lower levels in Th17 cells. It is known to synergize with Toll-like receptors and is thought to regulate Th1 and Th17 cytokine secretion.
References
Product Information
Format Purified
Control
  • Human thymus tissue lysate
Presentation Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Tim3 Antibody, clone 2E2 detects level of Tim3 & has been published & validated for use in WB, FC.
Key Applications
  • Western Blotting
  • Flow Cytometry
Application Notes Flow Cytometry Analysis: A 1:1,000 dilution of this antibody detected Tim3 in human monocyte derived dendritic cells.
Biological Information
Immunogen Recombinant protein corresponding to human Tim3.
Clone 2E2
Host Mouse
Isotype IgG1κ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
Gene Symbol
  • HAVCR2
  • TIM3
  • TIMD3
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Molecular Weight ~30 kDa observed.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in human thymus tissue lysate.

Western Blot Analysis: A 1:2,000 dilution of this antibody detected Tim3 in human thymus tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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