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Anti-T-bet (TBX21), clone 12E4.1 (mouse monoclonal)

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货号：MABF80

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R, M, H WB, FC M Purified Monoclonal Antibody
Description
Catalogue Number MABF80
Description Anti-T-bet (TBX21) Antibody, clone 12E4.1
Alternate Names
  • T-box transcription factor TBX21
  • T-box protein 21
  • T-cell-specific T-box transcription factor T-bet
  • Transcription factor TBLYM
Background Information TBX21 (T-box transcription factor, also known as T-Bet) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Studies in mouse show that TBX21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma. Expression of the human ortholog also correlates with IFN-G expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. TBX21 initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. Genetic variations in TBX21 are associated with susceptibility to asthma and nasal polyps.
References
Product Information
Format Purified
Control
  • PC-12 cell lysate
Presentation Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Applications
Application Detect T-bet (TBX21) using this Anti-T-bet (TBX21) Antibody, clone 12E4.1 validated for use in WB, FC.
Key Applications
  • Western Blotting
  • Flow Cytometry
Application Notes Flow Cytometry Analysis: A 1:50 dilution from a representative lot detected T-bet (TBX21) in PC-12 cells.

Western Blot Analysis: A 1:500 dilution from a previous lot detected T-bet (TBX21) in NIH/3T3 cell lysate.
Biological Information
Immunogen GST-tagged recombinant protein corresponding to human TBX21.
Clone 12E4.1
Host Mouse
Isotype IgMκ
Species Reactivity
  • Rat
  • Mouse
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined.
Gene Symbol
  • TBX21
  • TBET
  • TBLYM
Purification Method Purified by Ion-Exchange Chromatography
UniProt Number
UniProt Summary FUNCTION: Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.

SUBCELLULAR LOCATION: Nucleus.

TISSUE SPECIFICITY: T-cell specific.
Molecular Weight ~58 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in PC-12 cell lysate.

Western Blot Analysis: A 1:2,000 dilution of this antibody detected T-bet (TBX21) in PC-12 cell lysate.
Optimal dilution to be determined by end user.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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