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Anti-Dab1, clone EP2248Y, Rabbit Monoclonal

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货号：MABS167

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M ICC, IHC, IP, WB Rb Serum Polyclonal Antibody
Description
Catalogue Number AB5840
Replaces MABS167
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Dab1 Antibody
Alternate Names
  • Disabled homolog 1
Background Information Dab1 is a protein arising from the mouse gene dab, that is related to the Drosophila gene 'disabled'. Mutations in the mouse dab gene may result in the 'scrambler' and 'yotari' phenotypes. Dab encodes a phosphoprotein that binds non-receptor tyrosine kinases and has been implicated in neuron development. Dab1 is expressed in neuronal populations exposed to reelin, as determined by in situ hybridization to embryonic mouse brain tissue. Dab1 may function as a signaling molecule that regulates positioning in the developing brain. Cloning of human DAB1 and sequence determinations suggests a 96% homology to the mouse sequence. Very low density lipoprotein receptors (VLDLR) and apolipoprotein E receptor-2 (APOER2) both bind Dab1 on their cytoplasmic tails. Dab1 expression is upregulated in knockout mice lacking both Vldlr and Apoer2 genes.
References
Product Information
Format Serum
Control
  • Brain tissue
Presentation Delipidated and defibrinated Serum in 0.02M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% sodium azide.
Applications
Application This Anti-Dab1 Antibody is validated for use in IC, IH, IP, WB for the detection of Dab1.
Key Applications
  • Immunocytochemistry
  • Immunohistochemistry
  • Immunoprecipitation
  • Western Blotting
Application Notes Western blotting: 1:1,000-1:5,000

Immunocytochemistry: 1:500-1:1,000

Immunohistochemistry: 1:5,000-1:20,000 on cryofixed tissues

Immunoprecipitation

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Highly purified GST-fusion protein corresponding to residues 400-555 of mouse Dab1.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity On western blots of mouse brain extracts, the antibody recognizes a band migrating at approximately 80 kDa corresponding to Dab1. No cross reactivity to human or mouse Dab2.
Species Reactivity
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
Gene Symbol
  • DAB1
Purification Method Serum, delipidated and defibrinated
UniProt Number
UniProt Summary FUNCTION: SwissProt: O75553 # Adapter molecule functioning in neural development. May regulate SIAH1 activity (By similarity).
SIZE: 588 amino acids; 63775 Da
SUBUNIT: Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1 (By similarity). Interacts with LRP1.
DOMAIN: SwissProt: O75553 The PID domain specifically binds to the Asn-Pro-Xaa- Tyr(P) motif found in many tyrosine-phosphorylated proteins.
PTM: Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (By similarity). Also phosphorylated on Ser- 524 independently of reelin signaling (By similarity).
SIMILARITY: Contains 1 PID domain.
Molecular Weight 80 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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